Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

glial cells
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Amanda Heidt | Jun 10, 2021
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Astrocytes, Not Just Neurons, Play a Role in Sleep
Astrocytes, Not Just Neurons, Play a Role in Sleep
Abby Olena | Sep 24, 2020
In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.
Image of the Day: Biodegradable Nerve Guide
Image of the Day: Biodegradable Nerve Guide
Amy Schleunes | Jan 27, 2020
A polymer tube regenerates damaged nerves in monkeys, restoring near full functionality.
Microglia Cause Cognitive Decline in Obese Mice
Microglia Cause Cognitive Decline in Obese Mice
Diana Kwon | Sep 10, 2018
The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.
Reprogrammed Müller Glia Restore Vision in Mice
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Cellular Senescence in Astrocytes May Play Central Role in Parkinson’s Disease
Cellular Senescence in Astrocytes May Play Central Role in Parkinson’s Disease
Katarina Zimmer | Jan 24, 2018
The elimination of these glia in the mouse brain ameliorated the development of Parkinsonian neuropathologies induced by the pesticide toxin paraquat.  
Contributors
Contributors
Jef Akst and Katarina Zimmer | Jan 1, 2018
Meet some of the people featured in the January 2018 issue of The Scientist.
Pioneering Neuroscientist Dies
Pioneering Neuroscientist Dies
Diana Kwon | Jul 31, 2017
Marian Diamond, a former University of California, Berkeley, professor, discovered the first evidence for neuroplasticity and studied Einstein’s brain.
Image of the Day: Unseen Trauma
Image of the Day: Unseen Trauma
The Scientist Staff | Jun 20, 2017
Pressure from simulated blast waves, similar to those generated by explosives, induced molecular markers of stress and injury within mouse retinas.
Glia Guru
Glia Guru
Anna Azvolinsky | May 1, 2017
Ben Barres recast glial cells from supporting actors to star performers, crucial for synaptic plasticity in the brain and for preventing neurodegenerative disorders.
As the Brain Ages, Glial-Cell Gene Expression Changes Most
As the Brain Ages, Glial-Cell Gene Expression Changes Most
Ashley P. Taylor | Jan 10, 2017
Researchers describe how gene expression in different human brain regions is altered with age.
Immune System Maintains Brain Health
Immune System Maintains Brain Health
Amanda B. Keener | Nov 1, 2016
Once thought only to attack neurons, immune cells turn out to be vital for central nervous system function.
Into the Limelight
Into the Limelight
Kate Yandell | Oct 1, 2015
Glial cells were once considered neurons’ supporting actors, but new methods and model organisms are revealing their true importance in brain function.
Special Delivery
Special Delivery
Mary Beth Aberlin | Oct 1, 2015
Neurons in new brains and old