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Panels showing different kinds of microglia
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets
The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets
Mapping Tool Reveals Microglia’s Shape-Shifting Secrets

The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.

The approach could help test hypotheses about how atypical function of the brain’s immune cells contributes to autism.

glial cells
outline of a brain slice with white patch surrounded by teal
Astrocytes Feed Glioblastoma, Promoting Tumor Growth: Mouse Study
Patience Asanga | Oct 5, 2022 | 3 min read
Starving glioblastoma tumors of the cholesterol made by astrocytes could suppress brain cancer progression.
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022 | 3 min read
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
A reprogrammed astrocyte that can regenerate functional neurons.
Reprogramming Astrocytes: Unlocking DLX2’s Potential to Mend the Brain
Nele Haelterman, PhD | 3 min read
Scientists discover how to convert the brain’s glial cells into multipotent neural stem cells.
Photograph of Humsa Venkatesh
Humsa Venkatesh Probes Cancer’s Grip on the Brain
Maddie Bender | Aug 15, 2022 | 3 min read
At Brigham and Women’s Hospital, the cancer biologist is combining research into the tumor microenvironment with the principles of neuroscience to tease apart how cancers grow—and how to stop them.
Brain cells with electrical firing. 3D rendering.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021 | 10+ min read
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
LabTalk Podcast - Understanding Microglial Response in Alzheimer’s Disease
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
Single-cell technologies reveals subpopulations of microglia that play distinct roles in diseased and healthy brains.
Two oligodendrocyte progenitor cells are being generated from adult stem cells nestled on the surface of brain ventricle
Scientists Discover “Gorditas” and Other Novel Brain Cell Types
Amanda Heidt | Jun 10, 2021 | 5 min read
A pool of neural stem cells that ordinarily lies dormant in the brains of adult mice spawns two types of never-before-documented glial cells when artificially reactivated, potentially pointing to a novel mechanism of brain plasticity.
A microscopy image of a mouse brain that shows the lymphatic system in bright purple and pink
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021 | 5 min read
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
The Scientist's LabTalk Podcast - Episode 2
The Scientist’s Creative Services Team | 1 min read
Surviving Stress: The mysteries of neuronal survival and neurodegeneration
Astrocytes, Not Just Neurons, Play a Role in Sleep
Abby Olena, PhD | Sep 24, 2020 | 4 min read
In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.
polymer tube nerve regeneration
Image of the Day: Biodegradable Nerve Guide
Amy Schleunes | Jan 27, 2020 | 1 min read
A polymer tube regenerates damaged nerves in monkeys, restoring near full functionality.
Microglia Cause Cognitive Decline in Obese Mice
Diana Kwon | Sep 10, 2018 | 3 min read
The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Cellular Senescence in Astrocytes May Play Central Role in Parkinson’s Disease
Katarina Zimmer | Jan 24, 2018 | 4 min read
The elimination of these glia in the mouse brain ameliorated the development of Parkinsonian neuropathologies induced by the pesticide toxin paraquat.  
Contributors
Jef Akst and Katarina Zimmer | Jan 1, 2018 | 3 min read
Meet some of the people featured in the January 2018 issue of The Scientist.
Pioneering Neuroscientist Dies
Diana Kwon | Jul 31, 2017 | 2 min read
Marian Diamond, a former University of California, Berkeley, professor, discovered the first evidence for neuroplasticity and studied Einstein’s brain.
Image of the Day: Unseen Trauma
The Scientist Staff | Jun 20, 2017 | 1 min read
Pressure from simulated blast waves, similar to those generated by explosives, induced molecular markers of stress and injury within mouse retinas.
Glia Guru
Anna Azvolinsky | May 1, 2017 | 9 min read
Ben Barres recast glial cells from supporting actors to star performers, crucial for synaptic plasticity in the brain and for preventing neurodegenerative disorders.
As the Brain Ages, Glial-Cell Gene Expression Changes Most
Ashley P. Taylor | Jan 10, 2017 | 3 min read
Researchers describe how gene expression in different human brain regions is altered with age.
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