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Scientist hunched over a lab workbench in exhaustion

Neurotransmitter Buildup May Be Why Your Brain Feels Tired

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

Neurotransmitter Buildup May Be Why Your Brain Feels Tired

Neurotransmitter Buildup May Be Why Your Brain Feels Tired

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

Performing complex cognitive tasks leads to glutamate accumulating in a key region of the brain, a study finds, which could explain why mental labor is so exhausting.

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panel depicting mossy fiber synapses and glutamate signaling dynamics

Infographic: Reverse Signaling Between Neurons

Christie Wilcox, PhD | Jun 4, 2021 | 1 min read

So-called mossy fiber synapses in the hippocampus can meter the amount of neurotransmitter they receive by sending glutamate against the usual direction of synaptic flow.

artistic representation of a neuron synapse with light and dark dots passing between two axons

Hippocampal Cell Communication Is Bidirectional: Study

Christie Wilcox, PhD | Jun 4, 2021 | 6 min read

In an unexpected twist in neuroscience dogma, the cells on the receiving end of neurotransmission appear to be able to release glutamate to regulate the transmitting cell’s activity.

Harald Janovjak Bends Cells and Receptors to His Will

Aggie Mika | Oct 1, 2017 | 3 min read

The 38-year-old synthetic biologist comes from a long line of tinkerers and engineers.

Study: Eating Less Helps Worms Learn

Aggie Mika | Aug 2, 2017 | 2 min read

Food restriction decreases a metabolite that impedes associative learning in worms.

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