Using Genetic Cartography to Map Cell Lineage
Using Genetic Cartography to Map Cell Lineage
By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.
By coupling cell lineage tracking with molecular gene expression patterns, researchers deciphered how gene activity influences immune cell production.
hematopoietic stem cells
Low Intracellular Iron Levels May Keep Blood Stem Cells Young
Alejandra Manjarrez, PhD | Apr 8, 2024 | 3 min read
Removing excess iron from aging mouse blood-forming cells enhances their regenerative capacity.
Advanced Spatial Tools Map Hematopoietic Stem Cell Niches
Niki Spahich, PhD | Jan 15, 2024 | 4 min read
New technologies and archival tissue biopsy samples enable exploration of changes in the bone marrow as people age.
Unlocking the Secrets within Cells Using Next Generation Sequencing
The Scientist | 1 min read
Next generation sequencing (NGS) core facility scientists and researchers discuss their latest work exploring novel cancer models and stem cells in space.
Alcohol Leaves its Mark on Immune Cells
Shelby Bradford, PhD | Jan 1, 2024 | 2 min read
The immune system's recovery from chronic alcohol use could take longer than some rehabilitation periods due to alcohol's effects on stem cells.
Overcoming Cancer Therapy Obstacles With Epitope Editing
Rebecca Roberts, PhD | Oct 12, 2023 | 3 min read
Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.
How Can Core Labs Help You Get Started with NGS?
The Scientist | 1 min read
Next-generation sequencing (NGS) core facility scientists and researchers new to NGS discuss their fruitful collaborations, highlighting how to receive expert help from genomics facilities.
Northwestern University Stem Cell Therapy Clinic Closes Abruptly
Katarina Zimmer | Sep 6, 2019 | 5 min read
A Chicago-based center that has long operated a clinical trial program for stem cell therapies, has stopped recruiting further patients as its chief, Richard Burt, leaves for a research sabbatical.
Image of the Day: Powerful Protein
Chia-Yi Hou | Apr 25, 2019 | 1 min read
An experiment tests whether a protein treatment can help hematopoietic stem cells recover after mice are exposed to radiation.
Hematopoietic Stem Cells and Their Role in Development and Disease Therapy
Jennifer Zieba, PhD | 5 min read
Hematopietic stem cells (HSCs) are multipotent cells found in the blood and bone marrow with the ability to self-renew and differentiate into multiple cell types during bone marrow hematopoiesis
Alcohol Damages Mouse DNA
Jef Akst | Jan 3, 2018 | 1 min read
A byproduct of alcohol consumption causes mutations in the DNA of mouse blood stem cells, and some of the breaks are not repaired.
Top Technical Advances in 2017
Shawna Williams | Dec 24, 2017 | 3 min read
The year’s most impressive achievements include new methods to extend CRISPR editing, patch-clamp neurons hands-free, and analyze the contents of live cells.
LabTalk Podcast - Hijacking Genes: Uncovering the Cause of Lineage Ambiguous Leukemia
The Scientist | 1 min read
Chromosomal rearrangements reposition influential and often overlooked non-coding elements in the genome to hijack genes and cause cancer.
Vitamin C Depletion Accelerates Leukemia in Mice
Aggie Mika | Aug 21, 2017 | 2 min read
High levels of vitamin C absorbed by blood-forming stem cells are important for their normal development.
Vitamin C Blocks Leukemia Progression in Mice
Aggie Mika | Aug 17, 2017 | 3 min read
High-dose vitamin C injections reverse the effects of a leukemia-promoting genetic deficiency.
The MSC: Regeneration Orchestrator
The Scientist Staff | 7 min read
Scientists uncover the promise of mesenchymal stem cells (MSCs), also known as medicinal signaling cells, to modulate the immune system and regenerate tissue.
Blood Stem Cells Grown in the Lab
Ashley Yeager | May 17, 2017 | 3 min read
Researchers identify transcription factors and environmental conditions necessary to reprogram human and mouse cells into cells that function like hematopoietic stem cells.
Synthetic Bones: A Better Bone-Marrow Transplant?
Ashley P. Taylor | May 9, 2017 | 2 min read
Artificial bones produce new blood cells in mice, obviating the need for irradiation to kill off resident hematopoietic stem cells in recipients.
Multiomic Single-Cell Analysis Identifies a Unique Stem and Progenitor Population
The Scientist | 2 min read
Margaret Nakamoto will introduce the BD Rhapsody™ Single-Cell Analysis System, and Ravi Majeti will discuss how he and his team used concurrent RNA and BD® AbSeq Antibody-oligo multiplexed surface marker analysis to improve HSPC clustering and characterize specific phenotypic states along unique hematopoietic differentiation trajectories.
How to Track Cell Lineages As They Develop
Kelly Rae Chi | Dec 1, 2016 | 7 min read
Sequencing and gene-editing advances make tracing a cell’s journey throughout development easier than ever.