DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.
DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

histone modification
Infographic: A Yeast Model for Studying Histone Modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021
The methodology involves modifying histones and displaying them on the cell surface for analysis.
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Amanda Heidt | Sep 1, 2021
By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
Lasker Awards Recognize Work on Histones, Anesthesia, RNA
Lasker Awards Recognize Work on Histones, Anesthesia, RNA
Shawna Williams | Sep 11, 2018
This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.
As Bees Specialize, So Does Their DNA Packaging
As Bees Specialize, So Does Their DNA Packaging
Shawna Williams | Sep 11, 2018
A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.
Epigenetic Alterations Determine Ant Behavior
Epigenetic Alterations Determine Ant Behavior
Bob Grant | Jan 4, 2016
Histone modifications to the DNA of Florida carpenter ants can turn soldiers into foragers.
Gene Linked to Pain Insensitivity
Gene Linked to Pain Insensitivity
Kerry Grens | May 27, 2015
People with a congenital disorder that makes them unable to feel pain have mutations in a histone-modifying gene. 
Hidden Menace
Hidden Menace
John Frater, Genevieve Martin, Matthew Pace | May 1, 2015
Curing HIV means finding and eradicating viruses still lurking in the shadows.
Hide and Seek
Hide and Seek
The Scientist Staff | Apr 30, 2015
Oxford researcher John Frater explains the strategy of targeting viral reservoirs to beat HIV.
Pushing the Limits
Pushing the Limits
Marissa Fessenden | Feb 1, 2015
A guide to the newest techniques for examining epigenetics in single cells
Mighty Modifications
Mighty Modifications
Beth Marie Mole | Apr 1, 2013
Histone acetylation levels keep intracellular pH in check.
The Epigenetic Lnc
Kevin V. Morris | Oct 1, 2012
Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa
Boosting Antipsychotic Drugs
Ed Yong | Aug 5, 2012
Chemicals that change the way DNA is packaged could improve the effects of current antipsychotics.
The Sugar Lnc
Sabrina Richards | May 1, 2012
Genes that react to cellular sugar content are regulated by a long non-coding RNA via an unexpected mechanism
How Longevity Is Passed On
Cristina Luiggi | Oct 19, 2011
For the first time researchers have shown that epigenetic changes that increase lifespan can be inherited across multiple generations.
The Footprints of Winter
Ralf Müller and Justin Goodrich | Mar 1, 2011
Epigenetic marks laid down during the cold months of the year allow flowering in spring and summer.
Epigenetic Changes in Cancer
Manel Esteller | Mar 1, 2011
The study of how covalent marks on DNA and histones are involved in the origin and spread of cancer cells is also leading to new therapeutic strategies.
Epigenetics—A Primer
Stefan Kubicek | Mar 1, 2011
There are many ways that epigenetic effects regulate the activation or repression of genes. Here are a few molecular tricks cells use to read off the right genetic program.
Epigenetics—A Primer
Epigenetics—A Primer
Stefan Kubicek | Mar 1, 2011
Epigenetic events regulate the activities of genes without changing the DNA sequence. Different genes are expressed depending on the methyl-marks attached to DNA itself and by changes in the structure and/or composition of chromatin.