A view of the nucleus of a cell with DNA in blue, RNA in pink, and associated proteins in yellow and purple
DNA Methylation Influences Replication and Genome Organization
A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.
DNA Methylation Influences Replication and Genome Organization
DNA Methylation Influences Replication and Genome Organization

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

histones
Illustration showing how yeast is used to study histone modifications
Infographic: A Yeast Model for Studying Histone Modifications
Amanda Heidt | Sep 1, 2021
The methodology involves modifying histones and displaying them on the cell surface for analysis.
Saccharomyces cerevisiae yeast, 3D illustration. Microscopic fungi, baker's or brewer's yeast, are used as probiotics to restore normal flora of intestine
Yeast “Mini Labs” Help Researchers Probe Histone Modifications
Amanda Heidt | Sep 1, 2021
By harnessing a unique property of yeast, scientists can synthesize histones and the enzymes that modify these proteins, which spool DNA and influence gene expression.
Setting High Standards for Antibody Production Using Nucleosomes
Setting High Standards for Antibody Production Using Nucleosomes
Fortis Life Sciences
A unique approach to antibody production that exposes antibody candidates to nucleosomes is revolutionizing best practices.
obituary, obituaries, microbiology, molecular genetics, biochemistry, bioinformatics, Stanford University, University of Southern California, cell & molecular biology
Laurence “Larry” Kedes, Molecular Geneticist, Dies at 83
Amanda Heidt | Apr 26, 2021
In addition to isolating the first protein-coding gene from a eukaryote, Kedes furthered scientists’ understanding of actin genes and also laid the foundations for modern DNA databases such as GenBank.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
sperm epigenetics cancer risk heritability histones
Mice Inherit Cancer Susceptibility Via Epigenetic Changes in Sperm
Emma Yasinski | Apr 19, 2019
Mouse fathers whose sperm lacks the gene Kdm6a pass down altered methylation patterns to male offspring, along with a better chance of developing tumors and dying.
the Lasker award trophy
Lasker Awards Recognize Work on Histones, Anesthesia, RNA
Shawna Williams | Sep 11, 2018
This year’s winners are C. David Allis, Michael Grunstein, John Glen, and Joan Steitz.
As Bees Specialize, So Does Their DNA Packaging
Shawna Williams | Sep 11, 2018
A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.
Valerie Arboleda Uses Big Data to Unravel the Biology of a Rare Disease
Shawna Williams | May 1, 2018
The UCLA geneticist examines how defects in a histone protein lead to symptoms throughout the body.
Epigenetic Mechanism Tunes Brain Cells
Amanda B. Keener | Jul 2, 2015
Regular replacement of histones in human and murine neurons is required for neuronal plasticity, a study shows.
Silencing Surprise
Jenny Rood | Jun 1, 2015
A chromatin remodeler in embryonic stem cells clears the DNA for mRNA transcription while stifling the expression of noncoding transcripts.
Heritable Histones
Ruth Williams | Sep 18, 2014
Scientists show how roundworm daughter cells remember the histone modification patterns of their parents.
Stockpiling Histones
Kerry Grens | Feb 1, 2013
Histones stored on lipid droplets in fly embryos provide a backup supply when newly synthesized ones are lacking.
Conserved Chromatin?
Ed Yong | Dec 9, 2012
Archaea packages DNA around histones in a similar way to eukaryotes, suggesting that fitting a large genome into a small space was not the original role of chromatin.
A Reprogramming Histone
Beth Marie Mole | Oct 28, 2012
The scientist who pioneered cloning has found that a histone may act as a cellular reset button.  
The Epigenetic Lnc
Kevin V. Morris | Oct 1, 2012
Long non-protein-coding RNA (lncRNA) sequences are often transcribed from the opposite, or antisense, strand of a protein coding gene. In the past few years, research has shown that these lncRNAs play a number of regulatory roles in the cell. For exa
Flu Fights Dirty
Hayley Dunning | Sep 1, 2012
Mimicking a host-cell histone protein offers flu a sneaky tactic to suppress immune response.
Boosting Antipsychotic Drugs
Ed Yong | Aug 5, 2012
Chemicals that change the way DNA is packaged could improve the effects of current antipsychotics.
DNA, Contortionist
Kerry Grens | Aug 1, 2012
The DNA forms known as G-quadruplexes are finally discovered in human cells.