a white mouse huddles with several of her nine-day-old pups
In Vivo Gene Therapy Cures Infertility in Mice
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
ABOVE: © ISTOCK.COM, ANYAIVANOVA
In Vivo Gene Therapy Cures Infertility in Mice
In Vivo Gene Therapy Cures Infertility in Mice

Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

ABOVE: © ISTOCK.COM, ANYAIVANOVA

infertility

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The use of pronuclear transfer to treat infertility must first be backed by evidence it can work in cases where parents seek to avoid mitochondrial mutations.
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Among their many functions, macrophages in mouse testes guard sperm against attacks by other immune cells. 
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Using human pluripotent stem cells, scientists engineered an amniotic sac-like structure, potentially useful for uncovering the elusive cellular signals that lead to infertility.
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Sir Robert Edwards, whose research led to the birth of the first test tube baby, has died at age 87.