Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.

Researchers report they were able to make functional sperm in a dish, a feat previously only possible for mice.

For too long, a physiological inability to conceive or carry a child through to birth has been seen as a minor medical issue.

Hearing others’ perspectives on infertility and pregnancy has me reconsidering my own reproductive journey.

In human male-female pairs with a less similar suite of genes for human leukocyte antigens, sperm fare better when exposed to cervical mucus.

The controversial oogonial stem cells eluded a team of Swedish researchers who mapped high-quality tissue samples of the human ovary, prompting more questions about the cells’ existence.  

A cancer patient who underwent the new fertility preservation procedure successfully gave birth five years after her immature eggs were collected.

Oxidative stress associated with aging damages ovarian cells in both humans and nonhuman primates.

Proteins that synthesize, bind, and degrade endocannabinoids are present in the body’s sperm factories, suggesting that the use of cannabis may directly affect them.

Emails reveal that a facility in Dubai and others have asked geneticist He Jiankui for help in gene-editing embryos.

A company announces the first pregnancy in a study of whether donor mitochondria can boost IVF’s odds of success.

The use of pronuclear transfer to treat infertility must first be backed by evidence it can work in cases where parents seek to avoid mitochondrial mutations.

Among their many functions, macrophages in mouse testes guard sperm against attacks by other immune cells. 

Using human pluripotent stem cells, scientists engineered an amniotic sac-like structure, potentially useful for uncovering the elusive cellular signals that lead to infertility.

An app-based sperm analyzer screens for signs of male infertility.

Differences between cultures used for in vitro fertilization techniques can impact fertility and offspring health, researchers report.

The reprogrammed germ-like cells were unable to fertilize eggs, however. 

Scientists find a common genetic variant in mothers that decreases the chance of successful pregnancy.

A new study suggests that in the Spanish Habsburg royal family, natural selection may have diminished the most harmful effects of inbreeding.