A study looks beyond T and B cell responses to show how the Pfizer COVID-19 vaccine elicits a strong innate immune response.

The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.

A comparison of interferon-related genes across 20 primate genomes reveals differences in the speed at which they evolve and new targets for antiviral discovery efforts.

In a new study, human and mouse cells recognized only one in five bacterial species collected from more than a mile below the Pacific Ocean’s surface.

Paul Thomas from St. Jude Children’s Research Hospital will discuss how he used single cell and spatial transcriptomics to discover the underlying mechanism of an inflammatory immune response in the lungs.

A recent study sheds light on a previously unknown mechanism for fending off the pathogen, and potentially other viruses as well.

A pathway involved in the adaptive immune system, a relative newcomer in the world of pathogen defense, may have a more ancient role in protecting cells from invading viruses.

Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.

The rare complication known as multisystem inflammatory syndrome in children (MIS-C) differs from both Kawasaki disease and severe adult cases of COVID-19, a study finds.

These webs of chromatin and proteins, released by immune cells to control microbial infections, could serve as a therapeutic target in coronavirus infections.

The viral protein known as ORF3b limits the induction of the type I interferon response, which typically alerts other immune system components to the presence of a virus, in cultured cells.

Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.

This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.

In CRISPRed fruit flies that lack certain antimicrobial peptides, bacterial infections flourish, as revealed by fluorescent markers.

Immune cells in the mouse gut help recognize damaging compounds and prompt intestinal stem cells to repair DNA.

Limiting food intake leads to the conversion of white fat cells into more metabolically active brown fat cells through an immune response, a mouse study shows.

Three therapeutic doses administered during early life disturb the animals’ microbiomes and lead to enduring changes in the immune systems of non-obese diabetic mice, researchers report.

Alzheimer’s disease–associated amyloid-β peptides trap microbes in the brains of mice and in the guts of nematodes, a study shows. 

B and T cells may be the memory masters of the immune system, but research reveals that other cells can be primed by pathogens, too.