Tiliqua rugosa, sleepy lizard, on reddish soil in western Australia
Researchers Probe Genetics Behind a Lizard’s Odd Immune System
Deletions in the sleepy lizard genome leave it without an important type of T cells found in most other vertebrates.
Researchers Probe Genetics Behind a Lizard’s Odd Immune System
Researchers Probe Genetics Behind a Lizard’s Odd Immune System

Deletions in the sleepy lizard genome leave it without an important type of T cells found in most other vertebrates.

Deletions in the sleepy lizard genome leave it without an important type of T cells found in most other vertebrates.

innate immune system
Photo of a tiger moth
Antibiotics Given to Moths Spur Upregulation of Growth Genes
Devin A. Reese | Mar 1, 2022
A new study has identified a molecular tradeoff between growth and immunity in moths in response to the administration of subtherapeutic doses of antibiotics, a common practice in animal husbandry.
Colorized scanning electron micrograph of Salmonella bacteria in intestinal tissue
Gut Infections Help Shield Intestinal Neurons from Future Damage
Annie Melchor | Nov 19, 2021
In mice, a kind of immune memory appears to protect the cells against future harm, a finding that could provide insight into treatments for irritable bowel syndrome and other inflammatory digestive conditions.
Discover Genetic Influences on the Immune Response
The Genetics Behind Immune Response Variability
The Scientist Creative Services Team
Researchers seek genomic clues to understand differences in the immune response to infection.
Red blood cells are pictured in grayscale on a gray background
Red Blood Cells Activate Innate Immune System
Abby Olena | Oct 20, 2021
Researchers link the ability of the cells to bind and present DNA from pathogens and cell death to anemia, which is common in COVID-19, and immune activation.
Segmented filamentous bacteria artificially colored in green attach to the intestinal wall of a mouse
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
Understanding Immune-Mediated Damage After Respiratory Infection
The Scientist Creative Services Team in collaboration with 10x Genomics
Paul Thomas from St. Jude Children’s Research Hospital will discuss how he used single cell and spatial transcriptomics to discover the underlying mechanism of an inflammatory immune response in the lungs.
cartoon of a scientist holding a magnifying glass up to test tubes of blood
How the Second mRNA Vaccine Bolsters Immunity
Annie Melchor | Jul 23, 2021
A study looks beyond T and B cell responses to show how the Pfizer COVID-19 vaccine elicits a strong innate immune response.
A computer-generated graphic showing a cross-section of red-colored bacteria, with the locations of the protein APOL3 labeled in green.
Human Protein Dissolves Bacterial Membranes
Abby Olena | Jul 15, 2021
The protein, apolipoprotein L3, destroys invading microbes by acting as a detergent in the cytosol.
the molecular structure of interferon-alpha
Lots of Rapid Evolution in Interferon-Stimulated Genes: Study
Christie Wilcox | Jul 1, 2021
A comparison of interferon-related genes across 20 primate genomes reveals differences in the speed at which they evolve and new targets for antiviral discovery efforts.
Many Deep-Sea Microbes Invisible to Mammalian Immune System
Abby Olena | Mar 12, 2021
In a new study, human and mouse cells recognized only one in five bacterial species collected from more than a mile below the Pacific Ocean’s surface.
Infographic: A Cellular Defense Against Ebola Virus
Rachael Moeller Gorman | Dec 1, 2020
A recent study sheds light on a previously unknown mechanism for fending off the pathogen, and potentially other viruses as well.
Immune Genes Protect Cells from Ebola Virus and SARS-CoV-2
Rachael Moeller Gorman | Dec 1, 2020
A pathway involved in the adaptive immune system, a relative newcomer in the world of pathogen defense, may have a more ancient role in protecting cells from invading viruses.
Lipid Droplets Are Intracellular Bacteria-Fighting Machines
Ruth Williams | Oct 15, 2020
Far from being inert fat-storage depots within cells, these lipid-loaded organelles recruit immune proteins and block bacterial growth.
a child in a hospital bed
Kids’ Severe COVID-19 Reaction Bears Unique Immune Signature
Shawna Williams | Sep 29, 2020
The rare complication known as multisystem inflammatory syndrome in children (MIS-C) differs from both Kawasaki disease and severe adult cases of COVID-19, a study finds.
neutrophil extracellular traps NETs coronavirus covid-19 pandemic sars-cov-2 innate immune response immunity pathogen elastase chromatin DNA
Neutrophil Extracellular Traps May Augur Severe COVID-19
Alakananda Dasgupta | May 28, 2020
These webs of chromatin and proteins, released by immune cells to control microbial infections, could serve as a therapeutic target in coronavirus infections.
SARS-CoV-2 Protein Hampers Innate Immune Reaction In Vitro
Abby Olena | May 21, 2020
The viral protein known as ORF3b limits the induction of the type I interferon response, which typically alerts other immune system components to the presence of a virus, in cultured cells.
bcg tuberculosis tb sars-cov-2 covid-19 coronavirus pandemic vaccine nonspecific effects trained immunity innate immune system response
An Old TB Vaccine Finds New Life in Coronavirus Trials
Anthony King | May 4, 2020
Studies are underway to test whether giving a shot of BCG vaccine could protect doctors and nurses against COVID-19.
Novel DNA-Sensing Pathway Found in Human Cells, Absent in Mice
Catherine Offord | Jan 24, 2020
This previously unknown mechanism for spotting foreign genetic material in the cytoplasm launches antiviral defenses even when the well-known immune mediator STING is absent.
Image of the Day: An Infectious Glow
Carolyn Wilke | Mar 7, 2019
In CRISPRed fruit flies that lack certain antimicrobial peptides, bacterial infections flourish, as revealed by fluorescent markers.