When the Immune Response Makes COVID-19 Worse
When the Immune Response Makes COVID-19 Worse
If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.
When the Immune Response Makes COVID-19 Worse
When the Immune Response Makes COVID-19 Worse

If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.

If the immune system makes mistakes—reacting late or getting the target wrong—it can amplify the damage wrought by SARS-CoV-2.

interferon
Lots of Rapid Evolution in Interferon-Stimulated Genes: Study
Lots of Rapid Evolution in Interferon-Stimulated Genes: Study
Christie Wilcox | Jul 1, 2021
A comparison of interferon-related genes across 20 primate genomes reveals differences in the speed at which they evolve and new targets for antiviral discovery efforts.
Key Genes Related to Severe COVID-19 Infection Identified
Key Genes Related to Severe COVID-19 Infection Identified
Max Kozlov | Dec 14, 2020
Differences in the expression of genes associated with antiviral immunity and lung inflammation may contribute to a more serious COVID-19 infection.
SARS-CoV-2 Disables Key Components of Human Cells’ Defense System
SARS-CoV-2 Disables Key Components of Human Cells’ Defense System
Catherine Offord | Oct 22, 2020
Researchers detail how viral proteins interact with host RNA to disrupt the cell’s ability to fight back against infection.
Special Report
Seeking an Early COVID-19 Drug, Researchers Look to Interferons
Seeking an Early COVID-19 Drug, Researchers Look to Interferons
Alakananda Dasgupta | Jul 20, 2020
These antiviral proteins are produced by the body as a natural defense against viral infections and synthetic interferons might help prevent or treat the beginning stages of SARS-CoV-2 infection.
SARS-CoV-2 Protein Hampers Innate Immune Reaction In Vitro
SARS-CoV-2 Protein Hampers Innate Immune Reaction In Vitro
Abby Olena | May 21, 2020
The viral protein known as ORF3b limits the induction of the type I interferon response, which typically alerts other immune system components to the presence of a virus, in cultured cells.
Some Antibiotics Rev Up Host Immune Response to Viruses
Some Antibiotics Rev Up Host Immune Response to Viruses
Shawna Williams | Apr 9, 2018
The antimicrobial drug neomycin protects mice from some viral infections, complicating the picture of the relationship between antibiotics and susceptibility to viruses.
Maternal Response to Zika Damages Mouse Fetuses
Maternal Response to Zika Damages Mouse Fetuses
Catherine Offord | Jan 5, 2018
Signaling pathways triggered by the mother’s immune system may cause complications during fetal development.
Polio Vaccine Pioneer Dies
Polio Vaccine Pioneer Dies
Kerry Grens | May 2, 2017
Julius Youngner collaborated with Jonas Salk on the polio vaccine, and later identified interferon gamma and contributed to an equine influenza vaccine.
Culprit for Antibody Blockade Identified
Culprit for Antibody Blockade Identified
Amanda B. Keener | Oct 21, 2016
Type I interferon organizes several immune mechanisms to suppress B cell responses to a chronic viral infection.
One Way Placenta Deflects Zika Infection
One Way Placenta Deflects Zika Infection
Kerry Grens | Apr 5, 2016
Certain immune cells surrounding the organ appear to block viral entry.
Facing Down Emerging Viruses
Facing Down Emerging Viruses
Michal Barski | Feb 1, 2015
A better knowledge of the pathogenesis of emerging zoonotic diseases is crucial if we want to prepare for “the next Ebola.”
Interferon Discoverer Dies
Interferon Discoverer Dies
Kerry Grens | Jan 26, 2015
Jean Lindemann, the virologist who helped figure out that interferons were responsible for anti-viral responses, has passed away at age 90.
Long-Distance Call
Long-Distance Call
Rina Shaikh-Lesko | May 1, 2014
Neurons may use interferon signals transmitted over great distances to fend off viral infection.
Benjamin tenOever: Going Viral
Benjamin tenOever: Going Viral
Kerry Grens | Jan 1, 2014
Professor, Microbiology, Icahn School of Medicine at Mount Sinai. Age: 36
tenOever on microRNA and Vaccines
tenOever on microRNA and Vaccines
Kerry Grens | Dec 31, 2013
January 2014 Scientist to Watch Benjamin tenOever discusses his research.
Molecular Multitasking
Molecular Multitasking
Carina Storrs | Aug 1, 2013
Commercial kits use fluorescent beads to probe dozens of cytokines in one reaction.
Natural STD Protection for Women?
Natural STD Protection for Women?
Kate Yandell | Feb 28, 2013
An interferon found in the female reproductive tract may help guard against sexually transmitted diseases such as herpes.