close-up of a retina showing blood vessels and a damaged spot
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
DNA in Cell Cytoplasm Implicated in Age-Related Blindness

A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.

A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.

ABOVE: Jayakrishna Ambati, University of Virginia
LINE-1
retina atrophic age-related macular degeneration amd alu line-1 l1 retrotransposon cytoplasm cdna reverse transcription replication genome dna
Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez | Feb 8, 2021
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Mouse Moms’ Behavior Affects Pups’ Genome Structures
Abby Olena | Mar 22, 2018
Mice who get less attention from their mothers have more copies of a common retrotransposon in the genomes of their hippocampal neurons.
Age-Old Questions
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How do we age, and can we slow it down?