Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

lymphatics
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Quasi-Lymphatic System in the Rodent Eye Clears Waste
Abby Olena | Apr 16, 2020
Two rodent models of glaucoma have defects in the waste drainage system.
Image of the Day: Kidney Lymphatics
Image of the Day: Kidney Lymphatics
Amy Schleunes | Jan 15, 2020
Single-cell-resolution imaging offers a glimpse into lymphatic vessel formation in the mouse embryo.
Image of the Day: HIV Shuttles
Image of the Day: HIV Shuttles
Emily Makowski | Dec 5, 2019
Macrophages transport HIV-like particles into lymph nodes during infection.
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Brain’s Fluid Drains via Lymphatic Vessels at the Base of the Skull
Abby Olena | Jul 24, 2019
Detailed imaging of the rodent central nervous system reveals new information about the route cerebrospinal fluid takes to leave the brain.
Image of the Day: Gut Response
Image of the Day: Gut Response
Chia-Yi Hou | Jun 24, 2019
Immune functions in the mouse intestine differ by segment.
Lab-Generated Lymph Nodes Connect to Lymphatic System in Mice
Lab-Generated Lymph Nodes Connect to Lymphatic System in Mice
Ashley P. Taylor | Jun 4, 2019
Researchers hope that “lympho-organoids” could eventually treat lymphedema in humans, but the technique is currently a proof-of-concept.
Tattoo Ink Nanoparticles Persist in Lymph Nodes
Tattoo Ink Nanoparticles Persist in Lymph Nodes
Jef Akst | Sep 12, 2017
Analysis of the bodies of deceased individuals can’t determine what effect these tattoo remnants have on lymph function, but researchers suggest dirty needles aren’t the only risk of the age-old practice.
Transgenic Mouse Illuminates Melanoma Metastasis
Transgenic Mouse Illuminates Melanoma Metastasis
Abby Olena | Jun 28, 2017
Glowing cells mark the routes of tumor spread by way of newly formed lymph vessels. 
The Forces of Cancer
The Forces of Cancer
Lance L. Munn and Rakesh K. Jain | Apr 1, 2016
A tumor’s physical environment fuels its growth and causes treatment resistance.
Under Pressure
Under Pressure
Lance L. Munn and Rakesh K. Jain | Mar 31, 2016
The causes and consequences of physical forces in the tumor microenvironment
How Stress Affects Cancer’s Spread
How Stress Affects Cancer’s Spread
Catherine Offord | Mar 1, 2016
A mouse study reveals how chronic stress remodels lymphatic vasculature to facilitate the spread of tumor cells.
Contributors
Contributors
Amanda B. Keener | Aug 1, 2015
Meet some of the people featured in the August 2015 issue of The Scientist.
Rethinking Lymphatic Development
Rethinking Lymphatic Development
Amanda B. Keener | Aug 1, 2015
Four studies identify alternative origins for cells of the developing lymphatic system, challenging the long-standing view that they all come from veins.
Brain Drain
Brain Drain
Ashley P. Taylor | Jun 1, 2015
The brain contains lymphatic vessels similar to those found elsewhere in the body, a mouse study shows.
Lymphatic Lines
Edyta Zielinska | Aug 1, 2012
Lymphatic vessels grow towards two chemokines, revealing signals that could be important in cancer metastasis.