The Forces of Cancer

A tumor’s physical environment fuels its growth and causes treatment resistance.

Written byLance L. Munn and Rakesh K. Jain
| 10 min read

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© HYBRID MEDICAL/SCIENCE SOURCE

A helium balloon tugs gently at the end of its string. The tension in the string resists the buoyant force of the helium, and the elastic nature of the balloon’s rubber contains the helium gas as it tries to expand. Cutting the string or poking the rubber with a pin reveals the precarious balance between the forces, upsets the equilibrium, and sets the system into motion.

Some biological tissues also exist in such a state of offsetting forces. The most familiar example is the balance between blood pressure and the elastic tension in the cardiovascular system that contains and conveys blood without bursting or collapsing. And in tumors, both solid and fluid forces are generated that make the cancerous tissue a lot like that helium ...

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