Features

Microbes Meet Cancer
Microbes Meet Cancer
Kate Yandell | Apr 1, 2016
Understanding cancer’s relationship with the human microbiome could transform immune-modulating therapies.
A Different Way of Doing Things
A Different Way of Doing Things
Kivan├ž Birsoy and David M. Sabatini | Apr 1, 2016
Cancer cells exhibit altered metabolic processes that may serve as promising targets for new therapies.

Contributors

Contributors
Contributors
Contributors
Meet some of the people featured in the April 2016 issue of The Scientist.

Editorial

Shooting for the Moon
Shooting for the Moon
Shooting for the Moon
Defeating cancer is many times more difficult than planting a flag on our lunar satellite.

Speaking of Science

Speaking of Science
Speaking of Science
Speaking of Science
April 2016's selection of notable quotes

Notebook

A Tree  Takes Root
A Tree Takes Root
A Tree Takes Root
Four apparently unrelated individuals share a common ancestor from whom they inherited a rare mutation that predisposed them to the cancer they share.
Putting the Pee in Pluripotency
Putting the Pee in Pluripotency
Putting the Pee in Pluripotency
One man’s waste is another man’s treasure trove of stem cells.
The Two Faces of Fish Oil
The Two Faces of Fish Oil
The Two Faces of Fish Oil
The discovery of a tumor-protecting role for a fatty acid found in fish oil has sparked debate about the product’s safety.
Cancer Be Damned
Cancer Be Damned
Cancer Be Damned
Teenager Lauren Bendesky turned her cancer diagnosis on its head, using herself as a research subject to test potential therapies.

Critic at Large

Pet Scans
Pet Scans
Pet Scans
Studying tumor development and treatment in dogs and cats, in parallel with research on rodents and humans, could improve the successful translation of new cancer drugs.

Online First

Two-Way Traffic
Two-Way Traffic
Two-Way Traffic
In mice, malignant cells genetically modified to express an anticancer cytokine home in on tumors and reduce their growth.

Modus Operandi

Tumor-Shrinking Triple-Helices
Tumor-Shrinking Triple-Helices
Tumor-Shrinking Triple-Helices
A braided structure and some adhesive hydrogel make therapeutic microRNAs both stable and sticky.

Special Issue Feature

The Forces of Cancer
The Forces of Cancer
The Forces of Cancer
A tumor’s physical environment fuels its growth and causes treatment resistance.

The Literature

Cancer's Vanguard
Cancer's Vanguard
Cancer's Vanguard
Exosomes are emerging as key players in metastasis.
Tumor Traps
Tumor Traps
Tumor Traps
After surgery to remove a tumor, neutrophils recruited to the site spit out sticky webs of DNA that aid cancer recurrence.
Cancerous Conduits
Cancerous Conduits
Cancerous Conduits
Metastatic cancer cells use nanotubes to manipulate blood vessels.

Profile

Guts and Glory
Guts and Glory
Guts and Glory
An open mind and collaborative spirit have taken Hans Clevers on a journey from medicine to developmental biology, gastroenterology, cancer, and stem cells.

Scientist to Watch

Pradeep Chaluvally-Raghavan: Curious about Cancer
Pradeep Chaluvally-Raghavan: Curious about Cancer
Pradeep Chaluvally-Raghavan: Curious about Cancer
Instructor, Department of Systems Biology, University of Texas MD Anderson Cancer Center. Age: 38

Lab Tools

Pulling It All Together
Pulling It All Together
Pulling It All Together
Systems-biology approaches offer new strategies for finding hard-to-identify drug targets for cancer.
Written in Blood
Written in Blood
Written in Blood
A tour of evolving strategies for identifying circulating disease biomarkers

Bio Business

Banking on Blood Tests
Banking on Blood Tests
Banking on Blood Tests
How close are liquid biopsies to replacing current diagnostics?

Reading Frames

Parallel Plagues
Parallel Plagues
Parallel Plagues
Like cancer, ecological scourges result from the breakdown of regulatory processes, and may be treated with similar logic.

Capsule Reviews

Capsule Reviews
Capsule Reviews
Capsule Reviews
Lab Girl, The Most Perfect Thing, Half-Earth, and Cosmosapiens

Foundations

Fighting Cancer with Infection, 1891
Fighting Cancer with Infection, 1891
Fighting Cancer with Infection, 1891
Now hailed as the father of immunotherapy, William Coley pioneered extraordinary methods to treat cancer.