methodology

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Four ways to study mutation rate, a crucial statistic in studies of evolution

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The use of underperforming computational tools is a major offender in science’s reproducibility crisis—and there’s growing momentum to avoid it.

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An initiative to replicate key findings in cancer biology yields a preliminary conclusion: it’s difficult.

Researchers have discovered how to study coral organisms in unprecedented detail by mounting them in specially designed microscope slides.

A study suggests that gas chromatography-mass spectrometry modifies or destroys sample compounds, but some are skeptical.

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Submissions are officially open for this year’s Top 10 Innovations contest.

Living longer doesn’t necessarily mean living healthier.

Are mice, considered by some to be the less intelligent rodent, edging out rats as laboratory models of decision making?

Mice become stressed in the presence of male, but not female, experimenters, triggering a physiological response that dampens pain.

The federal agency speaks out about how to improve the quality of scientific research.

How visual materials and methods can save scientists time and money.

A precision microfluidic system enables single-cell analysis of growth and division.

Biomedical researchers would benefit from emulating the logically rigorous reasoning of the late Alan Turing, British mathematician, computer scientist, and master cryptographer.

Potential biases in scientific data collection and analysis should be minimized.

A lack of methodological detail in the published literature threatens the foundation of scientific discourse.