methods
Top Technical Advances in 2017
Top Technical Advances in 2017
Shawna Williams | Dec 24, 2017
The year’s most impressive achievements include new methods to extend CRISPR editing, patch-clamp neurons hands-free, and analyze the contents of live cells.
New Resource Ranks Chemical Probes for Human Proteins
New Resource Ranks Chemical Probes for Human Proteins
Abby Olena | Dec 14, 2017
With many probes being seriously flawed, Probe Miner helps researchers find those that are most specific and effective for manipulating their chosen proteins.
The Wada Test, 1948
The Wada Test, 1948
Philip Jaekl | Nov 1, 2017
A decades-old neurological procedure developed under unique and difficult conditions in postwar Japan remains critical to the treatment of epilepsy.
Implanted Magnetic Probes Measure Brain Activity
Implanted Magnetic Probes Measure Brain Activity
Ruth Williams | Nov 1, 2017
Micrometer-size magnetrodes detect activity-generated magnetic fields within living brains.
Infographic: Reading the Mind’s Magnetism
Infographic: Reading the Mind’s Magnetism
Ruth Williams | Oct 31, 2017
Newly designed sensors detect the magnetic fields generated by electrical activity within cat brains.
Scientists Who Developed Cryo-Electron Microscopy Win Nobel Prize
Scientists Who Developed Cryo-Electron Microscopy Win Nobel Prize
Diana Kwon | Oct 4, 2017
Chemistry Nobel goes to Jacques Dubochet, Joachim Frank, and Richard Henderson. 
Nonviral CRISPR Delivery a Success
Nonviral CRISPR Delivery a Success
Abby Olena | Oct 2, 2017
Researchers use gold nanoparticles to deliver CRISPR-Cas9 and correct a point mutation in a mouse model of Duchenne muscular dystrophy. 
Metabolomics Data Under Scrutiny
Metabolomics Data Under Scrutiny
Ashley P. Taylor | Sep 15, 2017
Out of 25,000 features originally detected by metabolic profiling of E. coli, fewer than 1,000 represent unique metabolites, a study finds.
Robotic Patch Clamping Gains Eyes
Robotic Patch Clamping Gains Eyes
Diana Kwon | Aug 30, 2017
Two groups of scientists combined automation with two-photon microscopy to target and record specific neurons in living animals. 
Chemogenetics Doesn’t Work Like Many Thought
Chemogenetics Doesn’t Work Like Many Thought
Kerry Grens | Aug 4, 2017
A study finds the so-called DREADD method of manipulating neurons using a drug called CNO actually works via clozapine.