Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

mouse models
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
Exercising During Pregnancy Protects Mouse Offspring
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Genome Reveals Clues to Giraffes’ “Blatantly Strange” Body Shape
Genome Reveals Clues to Giraffes’ “Blatantly Strange” Body Shape
Amanda Heidt | Mar 19, 2021
The physiological demands of that long neck get support from a gene involved in strengthening bones and blood vessels, researchers find after inserting the sequence in mice.
Early Embryo Models Generated from Mouse Stem Cells
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena | Oct 17, 2019
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
New Mouse Model Predicts Two Clinical Trial Failures in Humans
New Mouse Model Predicts Two Clinical Trial Failures in Humans
Emma Yasinski | Aug 1, 2019
The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.
Opinion: AI Beats Animal Testing at Finding Toxic Chemicals
Opinion: AI Beats Animal Testing at Finding Toxic Chemicals
Thomas Hartung | May 1, 2019
Machine learning could be the key to reducing the use of animals in experiments.
Image of the Day: Taken to Heart
Image of the Day: Taken to Heart
Carolyn Wilke | Mar 14, 2019
By zooming in on a developing mouse heart, scientists are studying whether defects in vasculature contribute to a thin muscle wall.
CAR T Cells Treat Lupus in Mice
CAR T Cells Treat Lupus in Mice
Abby Olena | Mar 6, 2019
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
Image of the Day: Mouse Tails
Image of the Day: Mouse Tails
Carolyn Wilke | Jan 24, 2019
Genetic mutations create lab mice with unusually long and short tails.
First Successful Gene Drive in Mammals
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
Former Students Allege Mistreatment of Lab Animals at Calgary<strong>&nbsp;</strong>
Former Students Allege Mistreatment of Lab Animals at Calgary 
Catherine Offord | Aug 9, 2018
The university is carrying out a review of animal handling in the now-closed lab of neuropsychologist Vedran Lovic.
Ultrasound Fires Up the Auditory Cortex—Even Though Animals Can’t Hear It
Ultrasound Fires Up the Auditory Cortex—Even Though Animals Can’t Hear It
Abby Olena | May 24, 2018
Researchers have been using ultrasound to control brain activity, but studies in mice and guinea pigs show it also stimulates the auditory system, presenting a confounder for direct neural stimulation.
Reprogrammed Cells Treat Diabetes in Mice
Reprogrammed Cells Treat Diabetes in Mice
Abby Olena | May 2, 2018
Researchers used a trio of transcription factors to transform pancreatic duct cells in vivo into β-like cells that secrete insulin and improve diabetes symptoms.
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Locally-Injected Immunotherapy Eradicates Tumors in Mice
Diana Kwon | Feb 1, 2018
The treatment also curbed the growth of nearby metastases that did not receive the drug.
“Retired” Mice Find New Life as Top Models for Autism
“Retired” Mice Find New Life as Top Models for Autism
Jessica Wright | Jan 28, 2018
After years of obscurity, strains of mice with mutations in particular genes are thrust to the fore of autism research.