mouse models

Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.

Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.

The physiological demands of that long neck get support from a gene involved in strengthening bones and blood vessels, researchers find after inserting the sequence in mice.

Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.

The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.

Machine learning could be the key to reducing the use of animals in experiments.

By zooming in on a developing mouse heart, scientists are studying whether defects in vasculature contribute to a thin muscle wall.

T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.

Genetic mutations create lab mice with unusually long and short tails.

Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.

The university is carrying out a review of animal handling in the now-closed lab of neuropsychologist Vedran Lovic.

Researchers have been using ultrasound to control brain activity, but studies in mice and guinea pigs show it also stimulates the auditory system, presenting a confounder for direct neural stimulation.