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A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

mouse models
A colored microscopy image of a dividing breast cancer cell
Transfer RNAs Have a Surprising Role in Breast Cancer Growth
Natalia Mesa, PhD | Jan 5, 2023 | 4 min read
A particular leucine-ferrying tRNA is more abundant in cancerous cells than healthy ones, and lowering its levels inhibits cancer growth, a study finds.
A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Alejandra Manjarrez, PhD | Oct 19, 2022 | 4 min read
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
Neurons traversing the brain with an area of red neurodegeneration
LabTalk Podcast - The New Era of Neurodegeneration Research
The Scientist’s Creative Services Team | 1 min read
Erdem Gültekin Tamgüney discusses the future of neurodegeneration research and his work exploring the link between stroke and Parkinson’s disease.
A mouse brain showing activated neurons (white) in the brainstem 3 hours after LPS injection.
Research Pinpoints the Neurons Behind Feeling Sick
James M. Gaines | Sep 23, 2022 | 5 min read
Specific neurons in the brainstem control sickness behaviors not directly caused by a pathogen, such as tiredness and lack of appetite, a mouse study finds.
Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.<br><br>
Immunotherapy Treats Fibrosis in Mice
Alejandra Manjarrez, PhD | Sep 15, 2022 | 4 min read
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells
LabTalk Podcast - Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells.
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022 | 3 min read
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | 2 min read
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
Scientific illustration of a migrating breast cancer cell.
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis
Alejandra Manjarrez, PhD | Feb 4, 2022 | 4 min read
A study uncovers a novel connection between the biomolecule and cancer progression.
grey and purple cancer cells under a microscope
Cell Diversity Could Spell Trouble for Animal Models of Cancer
David Adam | Nov 19, 2021 | 3 min read
Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  
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Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology
The Scientist’s Creative Services Team | 1 min read
Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.
white mouse on wheel
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Sophie Fessl, PhD | Sep 10, 2021 | 4 min read
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
One hand holds a white envelope with a blue and red striped border, while a second hand places a clear sheet of plastic inside with small squares of paper on it
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021 | 4 min read
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
Surveillance Gaps: How Cancer Arises
The Scientist’s Creative Services Team | 1 min read
Surveillance Gaps: How Cancer Arises
A black mouse runs on a yellow and green spinning wheel against a blue background
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021 | 2 min read
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
giraffe, genetics & genomics, CRISPR, gene editing, genome, physiology, hypertension, bone growth, techniques, mouse model
Genome Reveals Clues to Giraffes’ “Blatantly Strange” Body Shape
Amanda Heidt | Mar 19, 2021 | 5 min read
The physiological demands of that long neck get support from a gene involved in strengthening bones and blood vessels, researchers find after inserting the sequence in mice.
The Scientist Speaks Podcast - Episode 10
The Scientist’s Creative Services Team | 1 min read
Cancer Immunotherapy: CRISPR Reveals Targets In Vivo
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena, PhD | Oct 17, 2019 | 4 min read
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
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