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A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.

mouse models

Close-up image of fat cells
A Snapshot of How Obesity Transforms Fat
Aparna Nathan, PhD | Oct 5, 2023 | 3 min read
Spatial methods reveal immune cell formations in fat during early obesity.
Scientist pipetting at the bench in white coat and purple gloves
Chek-Mate for Gliomas
Aparna Nathan, PhD | May 22, 2023 | 3 min read
New research may make immunotherapy possible for hard-to-treat brain tumors.
<em >The Scientist</em>&rsquo;s Journal Club: Cancer
The Scientist’s Journal Club: Cancer
The Scientist | 1 min read
Scientists present the latest research on immune cell responses to cancer, the role of epigenetics in cancer, and molecular imaging of the tumor microenvironment.
A colored microscopy image of a dividing breast cancer cell
Transfer RNAs Have a Surprising Role in Breast Cancer Growth
Natalia Mesa, PhD | Jan 5, 2023 | 4 min read
A particular leucine-ferrying tRNA is more abundant in cancerous cells than healthy ones, and lowering its levels inhibits cancer growth, a study finds.
A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Alejandra Manjarrez, PhD | Oct 19, 2022 | 4 min read
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
Neurons traversing the brain with an area of red neurodegeneration
LabTalk Podcast - The New Era of Neurodegeneration Research
The Scientist | 1 min read
Erdem Gültekin Tamgüney discusses the future of neurodegeneration research and his work exploring the link between stroke and Parkinson’s disease.
A mouse brain showing activated neurons (white) in the brainstem 3 hours after LPS injection.
Research Pinpoints the Neurons Behind Feeling Sick
James M. Gaines | Sep 23, 2022 | 5 min read
Specific neurons in the brainstem control sickness behaviors not directly caused by a pathogen, such as tiredness and lack of appetite, a mouse study finds.
Histology of mouse lungs using purple and green staining on a white background. Left: a healthy lung. Right: a fibrotic lung.<br><br>
Immunotherapy Treats Fibrosis in Mice
Alejandra Manjarrez, PhD | Sep 15, 2022 | 4 min read
Researchers report that vaccination against proteins found on profibrotic cells reduced liver and lung fibrosis in laboratory rodents.
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells
LabTalk Podcast - Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
The Scientist and 10x Genomics | 1 min read
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells.
LAKSAMEE CAVE
Clinton Cave Investigates How Brain Cells Communicate
Andy Carstens | Sep 1, 2022 | 3 min read
The Middlebury College neuroscientist explores enzymes that affect brain cell development and neurodegeneration.
Fluorescent microscopy of a healthy intestinal organoid and a tumor spheroid
Internal Clock Disruptions Increase Colon Cancer Risk in Mice
Shafaq Zia | Aug 19, 2022 | 3 min read
Disturbing circadian rhythms in organoids and mice increases intestinal tumor growth, findings that may explain a recent rise in colon cancer among young adults, the researchers behind the work say.
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Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology
The Scientist | 1 min read
Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.
Scientific illustration of a migrating breast cancer cell.
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis
Alejandra Manjarrez, PhD | Feb 4, 2022 | 4 min read
A study uncovers a novel connection between the biomolecule and cancer progression.
grey and purple cancer cells under a microscope
Cell Diversity Could Spell Trouble for Animal Models of Cancer
David Adam | Nov 19, 2021 | 3 min read
Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  
Surveillance Gaps: How Cancer Arises
The Scientist | 1 min read
Surveillance Gaps: How Cancer Arises
white mouse on wheel
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Sophie Fessl, PhD | Sep 10, 2021 | 4 min read
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | Sep 10, 2021 | 2 min read
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
The Scientist Speaks Podcast - Episode 10
The Scientist | 1 min read
Cancer Immunotherapy: CRISPR Reveals Targets In Vivo
One hand holds a white envelope with a blue and red striped border, while a second hand places a clear sheet of plastic inside with small squares of paper on it
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021 | 4 min read
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
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