Green fluorescent semispherical object surrounded by tissue of the same color.
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis
A study uncovers a novel connection between the biomolecule and cancer progression.
ABOVE: © ISTOCK.COM, Christoph Burgstedt
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis
Breast Cancer Cells Churn Out Cholesterol to Fuel Metastasis

A study uncovers a novel connection between the biomolecule and cancer progression.

A study uncovers a novel connection between the biomolecule and cancer progression.

ABOVE: © ISTOCK.COM, Christoph Burgstedt

mouse models

grey and purple cancer cells under a microscope
Cell Diversity Could Spell Trouble for Animal Models of Cancer
David Adam | Nov 19, 2021
Tracking human cancers in mice shows some unexpected cell changes that could undermine translational research.  
white mouse on wheel
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Sophie Fessl | Sep 10, 2021
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells
LabTalk Podcast - Phagocidal Macrophages: A New Battle Tactic Against Resistant Cancers
The Scientist Creative Services Team, 10x Genomics | Nov 23, 2021
The adaptive and innate immune responses collaborate to attack T-cell resistant cancer cells.
One hand holds a white envelope with a blue and red striped border, while a second hand places a clear sheet of plastic inside with small squares of paper on it
Freeze-Dried Mouse Sperm Sent by Postcard Produces Baby Mice
Amanda Heidt | Aug 5, 2021
Rather than relying on samples that need to be shipped in glass vials and on ice, researchers have developed a new method that allows mouse sperm to be sent easily at room temperature using standard mail delivery.
A black mouse runs on a yellow and green spinning wheel against a blue background
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
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Heating Up CAR T Cells for Cancer Therapy
Roni Dengler, PhD | Sep 10, 2021
Heated gold nanoparticles unleash the therapeutic activity of engineered CAR T cells.
giraffe, genetics & genomics, CRISPR, gene editing, genome, physiology, hypertension, bone growth, techniques, mouse model
Genome Reveals Clues to Giraffes’ “Blatantly Strange” Body Shape
Amanda Heidt | Mar 19, 2021
The physiological demands of that long neck get support from a gene involved in strengthening bones and blood vessels, researchers find after inserting the sequence in mice.
Early Embryo Models Generated from Mouse Stem Cells
Abby Olena | Oct 17, 2019
Extended pluripotent stem cells from mice can self-organize to form blastocyst-like structures called blastoids that enable a closer look at early mammalian development.
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Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology
The Scientist Creative Services Team | Aug 9, 2021
Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.
mouse in grass microbiome
New Mouse Model Predicts Two Clinical Trial Failures in Humans
Emma Yasinski | Aug 1, 2019
The lab animals had more natural microbiomes seeded by wild mice, unlike conventional models that are kept in sterile conditions.
AI mice in labs
Opinion: AI Beats Animal Testing at Finding Toxic Chemicals
Thomas Hartung | May 1, 2019
Machine learning could be the key to reducing the use of animals in experiments.
Surveillance Gaps: How Cancer Arises
The Scientist Creative Services Team | Mar 15, 2021
Surveillance Gaps: How Cancer Arises
Image of the Day: Taken to Heart
Carolyn Wilke | Mar 14, 2019
By zooming in on a developing mouse heart, scientists are studying whether defects in vasculature contribute to a thin muscle wall.
CAR T Cells Treat Lupus in Mice
Abby Olena | Mar 6, 2019
T cells modified to target disease-contributing B cells improved survival in two mouse models of the autoimmune disease.
The Scientist Speaks Podcast - Episode 10
The Scientist Creative Services Team | Oct 28, 2020
Cancer Immunotherapy: CRISPR Reveals Targets In Vivo
Image of the Day: Mouse Tails
Carolyn Wilke | Jan 24, 2019
Genetic mutations create lab mice with unusually long and short tails.
First Successful Gene Drive in Mammals
Abby Olena | Jan 23, 2019
Researchers use a CRISPR-Cas9 strategy to expand a desired trait from 50 percent of mouse pups to about 72 percent.
Former Students Allege Mistreatment of Lab Animals at Calgary 
Catherine Offord | Aug 9, 2018
The university is carrying out a review of animal handling in the now-closed lab of neuropsychologist Vedran Lovic.
Ultrasound Fires Up the Auditory Cortex—Even Though Animals Can’t Hear It
Abby Olena | May 24, 2018
Researchers have been using ultrasound to control brain activity, but studies in mice and guinea pigs show it also stimulates the auditory system, presenting a confounder for direct neural stimulation.