A karyotype of chromosomes mostly stained blue with one stained red and green
Researchers Fuse Mouse Chromosomes in Scientific First
The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.
Researchers Fuse Mouse Chromosomes in Scientific First
Researchers Fuse Mouse Chromosomes in Scientific First

The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.

The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.

mouse study
microscope image series showing synthetic embryo development
Mouse Embryo: No Sperm, Egg, or Uterus Required
Christie Wilcox | Aug 2, 2022
Using stem cells and a bioreactor, researchers generated living embryos that survived for more than a week and began to develop internal organs.
salmonella bacteria 3d illustration
Salmonella Injection Helps the Mouse Immune System Kill Tumors
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria can capture tumor antigens and deliver them to immune cells, triggering a response that improved survival rates in mice.
Illustration showing how following radiation therapy, which triggers the release of cancer-specific antigens, researchers injected Salmonella typhimurium bacteria covered in positively charged nano- particles near tumors in mice.
Infographic: Salmonella Shuttle Tumor Antigens to Immune Cells
Dan Robitzski | May 16, 2022
Nanoparticle-coated bacteria carry cancer-derived proteins to dendritic cells, enabling the immune system to launch a response in a mouse model.
Image of sperm hooks (<em>Peromyscus maniculatus</em>)
The Mystery of the Mouse Sperm Hook
Natalia Mesa | May 2, 2022
Nearly all mouse sperm have hooks on their heads. But new research suggests the structures slow them down—so what exactly is their purpose?
Conceptual image of blue neurons with glowing segments over blue background.
CRACK Method Reveals Novel Neuron Type in Mouse Brain
Dan Robitzski | Apr 18, 2022
A new technique reveals cells’ precise locations and functions in the brain. Its developers have already used it to identify a previously unknown neuron type.
Illustration showing how calcium imaging and HCR-FISH combined is a technique called comprehensive readout of activity and cell type markers (CRACK)
Infographic: Simultaneously Studying Neuron Structure and Function
Dan Robitzski | Apr 18, 2022
A new methodology combines existing techniques to reveal the specific function and location of multiple types of neurons at once.
mice on wheel and ground
Exercise-Associated Protein Boosts Brain Function in Mice
Chloe Tenn | Dec 9, 2021
A study that transfused plasma from active to inactive mice suggests the protein clusterin enhances cognition.
Rounded red and green fluorescent cells are visible on a light and dark gray background
Neurons Firing Together Generate Spontaneous Pain
Abby Olena | Nov 10, 2021
Abnormal sympathetic neuron growth leads to simultaneous activation of clusters of sensory neurons, causing the difficult-to-treat sensation.
Illustration of neurons in white with myelin in blue
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Jef Akst | Oct 12, 2021
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Photograph of a brown laboratory mouse
Experiment Gone Awry Suggests Novel Way to Combat Hypoxia
Phil Jaekl | Oct 1, 2021
While exploring suspended animation in mice, scientists discover how an enzyme can protect the brain from dangerously low levels of oxygen.
Photograph of a mouse covering his face with his paw.
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Amanda Heidt | Oct 1, 2021
Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.
Illustration showing how a mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
Infographic: The Neural Pathway of Sneezing
Amanda Heidt | Oct 1, 2021
A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
One white mouse with red eyes runs on a blue exercise wheel, while another mouse stands with front paws on the wheel
Serious Infections Linked to Autism: Study
Abby Olena | Sep 17, 2021
In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.
A multicolored section of a fruit fly brain
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
ribbon model of phenylalanine hydroxylase enzyme
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Abby Olena | Aug 6, 2021
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
Segmented filamentous bacteria artificially colored in green attach to the intestinal wall of a mouse
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
A false-colored micrograph showing swirls of yellow, red, and magenta cells
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl | Jul 16, 2021
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Illustration of humans and mice and their gut microbiota
Infographic: Microbiome-Driven Adaptations in Animals
Catherine Offord | Jul 1, 2021
Researchers are using experiments and observational studies to look for host genetic variation that could be partly determined by the gut microbiota.