Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.

Researchers are using experiments and observational studies to look for host genetic variation that could be partly determined by the gut microbiota.

Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

Human stem cells injected into early monkey embryos proliferate and contribute to multiple cell lineages over 20 days of embryonic development.

Corticosterone interferes with signaling in the skin that normally activates hair follicle stem cells, possibly explaining the link between stress and hair loss.

A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.

Altered gut microbiome composition in obese mice and human patients is linked with severity of disease after bone marrow transplantation, a study found.

Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.

Neurological representations of different tastes—like those of different smells but unlike those of sight, hearing, and touch—do not cluster in distinct spots within a murine brain region, a study shows.

Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.

The effects seem to be mediated by a reactive oxygen species in the animals’ livers.

The results add to mounting evidence of microbes’ roles in tumor growth and point to the possibility of impeding malignancies by inhibiting bacteria.

In mice, the brain’s main glial cell type exhibits distinctive patterns of activity across the sleep-wake cycle and influences the response to sleep deprivation.

The animals develop a new memory that overrides the fearful one by inhibiting the cells that encode the original memory.

In mice, a group of nasal epithelial cells called brush cells release pro-inflammatory signals in response to allergens.

The drug, called memantine, could enter clinical trials to determine its effectiveness in humans.

The low-carb, high-fat diet increases the presence of gamma-delta T cells in the animals’ lungs, improving a mucus barrier against the virus.

A device implanted into mice can modulate brain circuit activity over long periods of time.