Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells
Repurposed Drug Reverses Signs of Alzheimer’s in Mice, Human Cells

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

mouse study
Experiment Gone Awry Suggests Novel Way to Combat Hypoxia
Experiment Gone Awry Suggests Novel Way to Combat Hypoxia
Phil Jaekl | Oct 1, 2021
While exploring suspended animation in mice, scientists discover how an enzyme can protect the brain from dangerously low levels of oxygen.
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Bless You: Mouse Model Reveals Molecular Pathway Behind Sneezing
Amanda Heidt | Oct 1, 2021
Researchers have identified specific cells and neuropeptides involved in mediating the sneeze response in mice exposed to allergens or chemical irritants such as capsaicin.
Infographic: The Neural Pathway of Sneezing
Infographic: The Neural Pathway of Sneezing
Amanda Heidt | Oct 1, 2021
A mouse study identifies the brain regions and specific signaling factors that regulate the sneeze response.
Serious Infections Linked to Autism: Study
Serious Infections Linked to Autism: Study
Abby Olena | Sep 17, 2021
In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.
Tumors Disrupt the Blood-Brain Barrier at a Distance
Tumors Disrupt the Blood-Brain Barrier at a Distance
Abby Olena | Sep 9, 2021
Shoring up the tissues that separate neurons and other brain cells from the circulatory system in fruit flies and mice can prolong life in the presence of a tumor.
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Abby Olena | Aug 18, 2021
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Noncoding RNA Improves Symptoms in Mice with Metabolic Disorder
Abby Olena | Aug 6, 2021
A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme.
Gut Microbes Help Coordinate Immune Activity in Mice
Gut Microbes Help Coordinate Immune Activity in Mice
Catherine Offord | Jul 29, 2021
The microbiota helps align a mouse’s innate immune system with its feeding patterns, prepping the animal to fend off infection when it’s most likely to be eating.
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Cross-Resistance: One Cancer Therapy Can Undermine the Next
Sophie Fessl | Jul 16, 2021
Targeted cancer therapy may jeopardize the effectiveness of subsequent immunotherapy by reducing dendritic cell numbers and activation, according to study of mice and patient samples.
Infographic: Microbiome-Driven Adaptations in Animals
Infographic: Microbiome-Driven Adaptations in Animals
Catherine Offord | Jul 1, 2021
Researchers are using experiments and observational studies to look for host genetic variation that could be partly determined by the gut microbiota.
Mammals Can Use Their Intestines to Breathe
Mammals Can Use Their Intestines to Breathe
Abby Olena | May 14, 2021
Researchers show that both mice and pigs are capable of oxygenating their blood via the colon—a capacity that, if shared by humans, could be leveraged in the clinic to minimize the need for mechanical ventilation.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Human-Monkey Chimeras Shed Light on Development
Human-Monkey Chimeras Shed Light on Development
Abby Olena | Apr 15, 2021
Human stem cells injected into early monkey embryos proliferate and contribute to multiple cell lineages over 20 days of embryonic development.
High Stress Hormone Levels Halt Mouse Fur Growth
High Stress Hormone Levels Halt Mouse Fur Growth
Jef Akst | Apr 1, 2021
Corticosterone interferes with signaling in the skin that normally activates hair follicle stem cells, possibly explaining the link between stress and hair loss.
Anesthesia Impairs Memory in Mice
Anesthesia Impairs Memory in Mice
Abby Olena | Apr 1, 2021
A study that compared several anesthetic regimens in rodents showed that only one—inhaled isoflurane—wasn’t detrimental to the activity of neurons in the hippocampus.
Obesity-Linked Gut Bacteria May Worsen Graft-Versus-Host Disease
Obesity-Linked Gut Bacteria May Worsen Graft-Versus-Host Disease
Asher Jones | Apr 1, 2021
Altered gut microbiome composition in obese mice and human patients is linked with severity of disease after bone marrow transplantation, a study found.
Early Training Forestalls Motor, Memory Difficulties in Mouse Model of Rett Syndrome
Early Training Forestalls Motor, Memory Difficulties in Mouse Model of Rett Syndrome
Laura Dattaro | Mar 29, 2021
Manipulating the activity of neurons active during training had similar effects on the mice’s behavior.
Neurons for Taste Loosely Distributed in Mouse Gustatory Cortex
Neurons for Taste Loosely Distributed in Mouse Gustatory Cortex
Jef Akst | Mar 1, 2021
Neurological representations of different tastes—like those of different smells but unlike those of sight, hearing, and touch—do not cluster in distinct spots within a murine brain region, a study shows.
Organoids Repair Bile Ducts
Organoids Repair Bile Ducts
Abby Olena | Feb 18, 2021
Researchers determined that when introduced into damaged mouse or donated human livers, these lab-grown tissues could integrate into bile ducts and function normally.