Discovering the Functions of Noncoding Sequence Variants
Discovering the Functions of Noncoding Sequence Variants
Neville Sanjana explored noncoding genomic regions by combining pooled CRISPR screening and single cell sequencing.
Neville Sanjana explored noncoding genomic regions by combining pooled CRISPR screening and single cell sequencing.
noncoding DNA
Q&A: Whole Genomes of 150,000 Britons Reveal Novel Genetic Variants
Sophie Fessl, PhD | Aug 5, 2022 | 5 min read
Height and onset of menarche are among traits linked to previously unidentified genetic variants in noncoding regions of the human genome.
Cancer-Specific Antigens Encoded in “Junk” DNA
Carolyn Wilke | Apr 1, 2019 | 2 min read
Researchers found that allegedly noncoding genetic material carries the instructions for many peptides that may help harness the immune system to fight cancer.
Most of Human Genome Nonfunctional: Study
Kerry Grens | Jul 17, 2017 | 2 min read
An estimate derived from fertility rates concludes that at least 75 percent of our DNA has no critical utility.
CRISPR Screen Detects Functional Gene Regulation
Abby Olena, PhD | Apr 3, 2017 | 3 min read
A CRISPR-Cas9–based method probes the regulatory roles of noncoding DNA sequences.
Capsule Reviews
Bob Grant | Apr 1, 2015 | 3 min read
Junk DNA, Cuckoo, Sapiens, and Cool
Genome Digest
Chris Palmer | Jun 19, 2013 | 5 min read
What researchers are learning as they sequence, map, and decode species’ genomes
Non-coding Mutations May Drive Cancer
Dan Cossins | Jan 24, 2013 | 3 min read
The majority of human melanomas contain mutations in a gene promoter, suggesting mutations in regulatory regions may spur some cancers.
Ginormous Genome
Sabrina Richards | May 1, 2012 | 1 min read
Researchers find organisms with huge genomes with high mutation rates, overturning a common expectation in evolutionary biology.