off-target effects

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

The authors propose that the shots might keep the immune system primed to battle diseases that would otherwise contribute to cognitive decline.

Machine learning algorithms predict the repairs made to DNA after Cas9 cuts.

After the reported birth of CRISPRed babies in China, experts want to take time to consider the scientific, social, ethical, and philosophical consequences of editing heritable human DNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

The DNA-cutting enzyme used in the technique is not as precisely targeted as scientists had thought, and investors take notice.

Last year, researchers claimed the gene-editing method had accuracy issues, but a new whole-genome sequencing analysis by the same team finds otherwise.

A new study finds that more than 200 human-targeted, non-antibiotic drugs inhibit the growth of bacterial species that make up part of the human microbiome.

Researchers have developed a variety of techniques to detect when CRISPR misses the mark.

A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.

Slight sequence differences confound target sites in precision genome-editing, a study shows.

A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.

Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.