New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

off-target effects
CRISPR Gene Editing Deletes, Shuffles More Genes than IntendedCRISPR Gene Editing Deletes, Shuffles More Genes than Intended
CRISPR Gene Editing Deletes, Shuffles More Genes than Intended
Ashley Yeager | Jul 16, 2018
The DNA-cutting enzyme used in the technique is not as precisely targeted as scientists had thought, and investors take notice.
Scientists Reverse Their Controversial Findings of CRISPR's Off-Target Effects
Scientists Reverse Their Controversial Findings of CRISPR's Off-Target Effects
Diana Kwon | Mar 28, 2018
Last year, researchers claimed the gene-editing method had accuracy issues, but a new whole-genome sequencing analysis by the same team finds otherwise.
Many Non-Antibiotic Drugs Affect Gut Bacteria
Many Non-Antibiotic Drugs Affect Gut Bacteria
Catherine Offord | Mar 20, 2018
A new study finds that more than 200 human-targeted, non-antibiotic drugs inhibit the growth of bacterial species that make up part of the human microbiome.
New Methods to Detect CRISPR Off-Target Mutations
New Methods to Detect CRISPR Off-Target Mutations
Sandeep Ravindran | Mar 1, 2018
Researchers have developed a variety of techniques to detect when CRISPR misses the mark.
Most Accurate CRISPR Gene Editing Yet
Most Accurate CRISPR Gene Editing Yet
Kerry Grens | Sep 22, 2017
A tweaked Cas9 nuclease reduces off-target effects to levels below that of previous versions of the enzyme.
Human Genetic Variation May Complicate CRISPR
Human Genetic Variation May Complicate CRISPR
Ashley Yeager | Jul 31, 2017
Slight sequence differences confound target sites in precision genome-editing, a study shows.
Was a Drop in CRISPR Firms’ Stock Warranted?
Was a Drop in CRISPR Firms’ Stock Warranted?
Claire Asher | Jun 7, 2017
A study of off-target effects that sparked fear among investors of genome-editing companies receives methodological criticisms.
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Using CRISPR to Edit Genes in Induced Pluripotent Stem Cells
Kelly Rae Chi | Sep 1, 2016
Tips on how to surmount the challenges of working with CRISPR to manipulate genes in human stems cells to study their function in specific diseases or to correct genetic defects in patient cells.