organelle

The discovery of gene variants in cases of hereditary spastic dysplasia could provide a diagnosis to affected families where no genetic cause could be found before.

The University of California, Santa Barbara, cell biologist is investigating the formation and functions of the peroxisome, an organelle which exists in many copies in each cell and can be created, lost, or altered to meet the cell’s metabolic needs.

A technique that reversibly bundles tagged cargo into artificial membraneless compartments gives scientists the ability to switch cell processes on and off.

Engineered cells produce proteins that allow scientists to turn cellular processes on and off.

The functional, respiring organelles appear to be present in the blood of healthy people, but their function is yet unclear.

What do scientists know about this membraneless nuclear body discovered less than two decades ago?

Discovering a new type of subnuclear body taught me how pursuing the unexpected can lead to new insights—in this case, about long noncoding RNAs and liquid-liquid phase separation in cells.

Membraneless organelles appear highly sensitive to ion concentrations in their environment.

Microscope-mounted magnets with computerized feedback control allow precision manipulations of intracellular objects.

Optimized tweezers enable precise 3-D manipulations of a cell’s organelles.

Microbes, traditionally thought to lack organelles, get a metabolic boost from geometric compartments that act as cauldrons for chemical reactions. Bioengineers are eager to harness the compartments for their own purposes.

These icosahedral structures are composed of proteins with unique geometric properties, which enable bacteria to employ them in a variety of situations.

The physical principles that dictate the formation of these subcellular compartments are simple, but they dictate the organelles’ complex functions.

From making ribosomes to protecting the integrity of the genome, these membraneless compartments play important roles in the cell. Their behavior is rooted in basic physics.

Günter Blobel, known for his work on the signal hypothesis of protein targeting, has died from cancer at age 81.

Solving a long-standing structural puzzle will open the door to understanding one of the cell’s most enigmatic machines.

The ribosome-associated organelle consists of tightly packed tubes, not flat sheets as previously believed, according to new super-resolution microscopy images.

Without a vacuole, cell-cycle progression stalls out in yeast cells.

Deficiency in a protein called pejvakin makes inner ear cells more vulnerable to sound, unable to brace themselves against oxidative stress stimulated by noise.