PEG GERRITY
These tiny subnuclear bodies typically measure 360 nanometers in diameter. They are composed of a long noncoding RNA (lncRNA) molecule called NEAT1, which serves as the seed. Proteins that bind to NEAT1 accumulate, self-associate, and recruit other proteins, forming a mature paraspeckle.
Peg gerrity
When a cell is stressed, various triggers can cause it to increase the production of the lncRNA NEAT1, leading to the formation of more paraspeckles. These bodies can grow to up to 2 micrometers in length, changing from a spherical shape to oblong and sometimes branched structures. They trap various proteins and mRNAs, hindering their function and thereby affecting the cell’s continued response to stress.
PEG GERRITY
| 1 | As they accumulate proteins and RNAs, paraspeckles can become linked together, growing bigger, oblong, and sometimes branched. |
| 2 | Greater abundance of NEAT1 leads to more paraspeckles. |
| 3 | Specific messenger RNAs become trapped in paraspeckles and... |
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