A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

phase separation
Illustration of blue and gray amino acids loosely forming protein
Fungal Cold Adaptation Linked to Protein Structure Changes: Study
Patience Asanga | Sep 20, 2022
Environmental pressure seems to spawn changes in the intrinsically disordered regions of enzymes in polar yeasts, allowing them to adapt to extreme cold.
oil in water
Stress-Induced Molecular Globs Boost Bacterial Fitness
Ruth Williams | Oct 21, 2021
Liquid conglomerations of molecules that form in bacterial cells in response to stress promote the cells’ survival, a study finds.
Newly Found Proteins Stop Fungal “Bleeding”
Viviane Callier | Nov 12, 2020
Mechanically sensitive proteins called gellins sense and respond to protoplasm flowing out of severed hyphae, quickly sealing up injuries in these root-like structures of fungi.
Infographic: Paraspeckle Form and Function
Archa Fox | Dec 1, 2019
What do scientists know about this membraneless nuclear body discovered less than two decades ago?
What Paraspeckles Can Teach Us About Basic Cell Biology
Archa Fox | Dec 1, 2019
Discovering a new type of subnuclear body taught me how pursuing the unexpected can lead to new insights—in this case, about long noncoding RNAs and liquid-liquid phase separation in cells.
Infographic: What Are Membraneless Organelles?
Michael Crabtree and Tim Nott | Dec 1, 2018
The physical principles that dictate the formation of these subcellular compartments are simple, but they dictate the organelles’ complex functions.