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2022 Top 10 Innovations
2022 Top 10 Innovations
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2022 Top 10 Innovations
2022 Top 10 Innovations

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

personalized medicine
Illustration of light blue speckled DNA helix on a dark background
Study Nearly Doubles Known Cancer-Linked Mutational Signatures
Jef Akst | Apr 22, 2022 | 2 min read
Analyzing the whole genome sequences of more than 18,000 tumors, researchers catalog nearly 60 new patterns of mutations that could inform cancer treatment.
a smiling woman standing between a much taller man and woman
Protein Size Matters
David Adam | Sep 23, 2021 | 3 min read
A study probes how genetic duplications that can swell protein length influence human traits such as height and kidney function.
Two babies engaged in conversation, with one shouting in the other’s ear
Nurturing Early Language Skills Prevents the Behavioral Expression of a Genetic Trait
Iris Kulbatski, PhD | 4 min read
A new precision medicine approach is making life sweeter for infants unable to metabolize milk sugar.
A vial containing a red blood sample is balanced on its end on a table or desk by someone wearing a blue medical glove on their right hand
New Evidence Shows COVID-19 Was in US Weeks Before Thought
Abby Olena, PhD | Jun 17, 2021 | 4 min read
Some of the blood specimens collected in the United States for the NIH’s All of Us research program starting on January 2, 2020, have antibodies against SARS-CoV-2.
smart pills
Smart Pills Help Monitor Cancer Patients’ Therapy
Chia-Yi Hou | Jul 15, 2019 | 5 min read
Sensors encapsulated with oral chemotherapy drugs help patients and physicians keep track of treatments.
Performing Metabolomic and Functional Proteomic Analyses on a Heterogenous Cancer Cell Population
The Scientist Creative Services Team in Collaboration with IsoPlexis | 2 min read
A tumor metabolome panel identifies altered cell states that lead to drug tolerance.
Contributors july august the scientist
Contributors
The Scientist Staff | Jul 15, 2019 | 3 min read
Meet some of the people featured in the July/August 2019 issue of The Scientist.
Opinion: Applying AI to Clinical Care Is Key to Individualized Medicine
Opinion: Applying AI to Clinical Care Is Key to Individualized Medicine
Eric Topol | Jul 15, 2019 | 3 min read
Not only can artificial intelligence revolutionize healthcare, it could help restore the doctor-patient relationship.
3-D Treatment
Tumor Organoids Hold Promise for Personalizing Cancer Therapy
Jef Akst | Jul 15, 2019 | 4 min read
The three-dimensional cell cultures are still in the development phase, but researchers are excited about their use to predict patients’ responses to various treatment options.
Topol on Deep Medicine
The Scientist Staff | Jul 15, 2019 | 1 min read
Eric Topol, founder and director of Scripps Research Translational Institute and Reading Frames author, discusses the future of the doctor-patient bond in an era of artificial intelligence–driven medicine.
Orkin on Childhood Cancer
The Scientist Staff | Jul 15, 2019 | 1 min read
This month’s Profilee, Dana-Farber Cancer Institute researcher Stuart Orkin, talks about treating kids with cancer and other blood disorders.
Chronic lymphocytic leukemia
T Cell Proliferation Linked to CAR T Responses
Ashley Yeager | Jul 15, 2019 | 2 min read
Comparing the cells of cancer patients who did and did not respond to the immunotherapy could reveal biomarkers to predict who should receive it in the first place.
predicts future emergency room visits
Researchers Identify Biomarkers for Pain in Blood Samples
Chia-Yi Hou | Jul 15, 2019 | 2 min read
The expression of a slew of genes in psychiatric patients closely tracks pain intensity and predicts future emergency room visits, according to a study.
personalized vaccines
Infographic: Neoantigen Prediction for Personalized Vaccine Design
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 3 min read
See how a computational pipeline uses next-generation sequencing data to identify genetic alterations that produce cancer-specific antigens.
custom targeted cancer vaccine
Personalized Cancer Vaccines in Clinical Trials
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 10+ min read
The field is young, but predicting antigens produced by patients’ malignant cells could yield successful treatments for individuals with a range of cancer types.
Table: Personalized Cancer Vaccine Trials in the United States
Jasreet Hundal and Elaine R. Mardis | Jul 15, 2019 | 6 min read
There are currently more than two dozen ongoing Phase 1 and Phase 2 trials using different vaccine platforms such as DNA, RNA, synthetic long peptides, and dendritic cells.
microbiome drugs
How the Microbiome Influences Drug Action
Shawna Williams | Jul 15, 2019 | 10+ min read
Through their effects on metabolism and immunity, bacteria in the gut affect whether medications will be effective for a given patient.
NIH Plans to Enroll 1 Million People for Health Database
Catherine Offord | May 3, 2018 | 2 min read
The agency says it has taken various steps to ensure the privacy of participants’ data. 
Estonia Offers Free Genetic Testing to Residents
Diana Kwon | Apr 13, 2018 | 1 min read
The nationwide experiment will initially include around 100,000 volunteers.
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