Endolysosome leakiness allows tau to build up in cells.

The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.

The neurodegenerative disease shares protein clumps in common with appendixes, perhaps explaining why removing the organ is protective.

A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 

By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.

Contrary to years of research suggesting otherwise, most aggregated proteins regain their shape and functionality following heat shock.

Researchers show that pathogenic protein aggregates that accumulate within neurons and are a hallmark of Huntington’s disease can propagate from cell to cell.

Researchers earn applause after recalling two papers containing misinterpreted findings.

Properly folded prions aid in normal brain development.

Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39

New findings challenge long-held views about the mechanism yeast cells use to live forever.