protein aggregating

Engineered cells produce proteins that allow scientists to turn cellular processes on and off.

Liquid conglomerations of molecules that form in bacterial cells in response to stress promote the cells’ survival, a study finds.

Researchers say they hope to launch a clinical trial to test bumetanide, a diuretic approved in 2002, but how it might improve neural functioning is unclear.

Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.

The single-celled fungus allows researchers to study Alzheimer’s, Parkinson’s, ALS and other brain diseases with unparalleled speed and scale.

Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.

Endolysosome leakiness allows tau to build up in cells.

The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.

The neurodegenerative disease shares protein clumps in common with appendixes, perhaps explaining why removing the organ is protective.

A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 

By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.

Contrary to years of research suggesting otherwise, most aggregated proteins regain their shape and functionality following heat shock.

Researchers show that pathogenic protein aggregates that accumulate within neurons and are a hallmark of Huntington’s disease can propagate from cell to cell.

Researchers earn applause after recalling two papers containing misinterpreted findings.

Properly folded prions aid in normal brain development.

Senior Scientist, Millennium Pharmaceuticals: The Takeda Oncology Company Age: 39

New findings challenge long-held views about the mechanism yeast cells use to live forever.