“Hero” Proteins May Shield Other Proteins from Harm
“Hero” Proteins May Shield Other Proteins from Harm
Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.
“Hero” Proteins May Shield Other Proteins from Harm
“Hero” Proteins May Shield Other Proteins from Harm

Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.

Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.

protein aggregating
Image of the Day: Tau Aggregation
Image of the Day: Tau Aggregation
Emily Makowski | Oct 17, 2019
Endolysosome leakiness allows tau to build up in cells.
Chemist Christopher Dobson Dies
Chemist Christopher Dobson Dies
Ashley Yeager | Sep 16, 2019
The University of Cambridge scholar’s research on folding proteins advanced scientists’ understanding of illnesses, such as Alzheimer’s disease, Parkinson’s disease, and type 2 diabetes.
Appendectomy May Lower Risk of Parkinson’s DiseaseAppendectomy May Lower Risk of Parkinson’s Disease
Appendectomy May Lower Risk of Parkinson’s Disease
Ashley Yeager | Oct 31, 2018
The neurodegenerative disease shares protein clumps in common with appendixes, perhaps explaining why removing the organ is protective.
Detecting Protein Clumps
Detecting Protein Clumps
Ruth Williams | Jan 31, 2018
A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 
Image of the Day: When Cells Stop Cleaning
Image of the Day: When Cells Stop Cleaning
The Scientist Staff | Sep 12, 2017
By stifling autophagy in the motor neurons of a mouse model of amyotrophic lateral sclerosis (ALS), scientists stem later-stage disease progression.
Getting Back in Shape
Getting Back in Shape
Karen Zusi | Nov 30, 2015
Contrary to years of research suggesting otherwise, most aggregated proteins regain their shape and functionality following heat shock.
Neurodegeneration’s Spread
Neurodegeneration’s Spread
Ashley P. Taylor | Aug 3, 2014
Researchers show that pathogenic protein aggregates that accumulate within neurons and are a hallmark of Huntington’s disease can propagate from cell to cell.
Mea Culpa Retractions
Mea Culpa Retractions
Kerry Grens | Aug 30, 2013
Researchers earn applause after recalling two papers containing misinterpreted findings.
Prions Involved in Learning
Prions Involved in Learning
Edyta Zielinska | Feb 15, 2013
Properly folded prions aid in normal brain development.