A ball-and-stick plus ribbons molecular model of the hormone orexin, also known as hypocretin, isolated on a white background.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy
2023 Breakthrough Prizes Showcase Research in AI and Narcolepsy

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

Three prizes were awarded to six researchers working across the life sciences on cellular organization, protein structure, and the genetic underpinnings of a chronic sleep disorder.

protein folding
A micrograph of the prion-like state of a protein called Pus4
Protein Mediates Non-Genetic Inheritance of Growth Strategies
Catherine Offord | Jan 4, 2022
An RNA-modifying enzyme passed to daughter cells during budding allows yeast cells to switch between faster- and slower-growing phenotypes.
An illustration of a yeast cell (right) and a human neuron (left) showing the processes/features that are similar in the two
Infographic: Modeling Neurodegenerative Diseases with Yeast
Mahlon Collins | Oct 1, 2021
Conservation of structures and functions between single-celled fungi and human cells allow researchers to probe the brain.
Discover how glycosylation affects health and disease
Exploring the World of Glycobiology
The Scientist Creative Services Team and Vector Laboratories
Researchers study sugar modifications to understand health and disease.
Q8W3K0, listed in the DeepMind database as a potential plant disease resistance protein from Arabidopsis thaliana
Predictions of Most Human Protein Structures Made Freely Available
Lisa Winter | Jul 23, 2021
The AlphaFold program from AI firm DeepMind has amassed a huge database of protein structures from humans and model organisms.
Robert “Buzz” Baldwin, Early Expert in Protein Structures, Dies
Jef Akst | Apr 2, 2021
Research by the Stanford University School of Medicine professor revealed how newly formed strings of amino acids fold into complex three-dimensional shapes.
Examine Altered Glycobiology in Cancer
Examining Altered Glycobiology in Cancer
The Scientist Creative Services Team and Vector Laboratories
Changes to protein glycosylation play a major role in dictating cancer progression and prognosis, but could they also present biomarkers or therapeutic targets?
DeepMind AI Speeds Up the Time to Determine Proteins’ Structures
Lisa Winter | Dec 2, 2020
The technology solves proteins’ 3-D shapes in minutes, when traditional methods may take years.
Newly Found Proteins Stop Fungal “Bleeding”
Viviane Callier | Nov 12, 2020
Mechanically sensitive proteins called gellins sense and respond to protoplasm flowing out of severed hyphae, quickly sealing up injuries in these root-like structures of fungi.
Undone Proteins Take Out Bladder Cancer
Roni Dengler, PhD
An unfolded protein found in human milk shows promise in early clinical trials to treat bladder cancer.
“Hero” Proteins May Shield Other Proteins from Harm
Emma Yasinski | Mar 19, 2020
Flexible proteins appear to protect molecules from becoming denatured in extreme conditions such as heat and from clumping up, as happens in some neurodegenerative diseases.
Scientists Use Online Game to Research COVID-19 Treatment
Emma Yasinski | Mar 9, 2020
The creativity of citizen scientists could help researchers design proteins that may be able to fight the SARS-CoV-2 virus.
Detecting Protein Clumps
Ruth Williams | Feb 1, 2018
A synthetic genetic tool called yTRAP allows high-throughput detection of protein aggregates in cells.
 
Drugging the Disorderome
Amber Dance | Oct 1, 2017
Strategies for targeting intrinsically disordered proteins
Fascinated by Folding
Anna Azvolinsky | Aug 3, 2017
Lila Gierasch uses biochemical tools to understand how linear chains of amino acids turn into complex three-dimensional structures.
Unknown Protein Structures Predicted
Ruth Williams | Jan 19, 2017
Metagenomic sequence data boosts the power of protein modeling software to yield hundreds of new protein structure predictions.
Bacterial Protein Acts as Prion in Yeast and E. coli
Jef Akst | Jan 16, 2017
Clostridium botulinum produces a transcription factor that can aggregate and self-propagate a prion-like form, leading to genome-wide changes in gene expression in E. coli, according to a study.
Vlad Denic on Exploring New Fields and Failing Successfully
Ben Andrew Henry | Dec 1, 2016
The Harvard professor is pursuing fundamental questions about autophagy, protein homeostasis, and other cellular processes, and he’s always on the lookout for his next new topic.
Protein Folding Pioneer Dies
Kerry Grens | Oct 28, 2016
Susan Lindquist of MIT and the Whitehead Institute broke scientific ground on prions and heat shock proteins.
Prions in Plants?
Tanya Lewis | Apr 26, 2016
A plant protein that behaves like a prion when inserted into yeast could enable a form of botanical memory, a study suggests.