Light shines through a dilated pupil to illuminate the light red retina, blood vessels, optic disc and macula.
Gut Bacteria Slip into the Eye
A gene mutation causes porous gut and retinal barriers, allowing bacteria to travel from one to the other, triggering retinal degeneration in mice.
Gut Bacteria Slip into the Eye
Gut Bacteria Slip into the Eye

A gene mutation causes porous gut and retinal barriers, allowing bacteria to travel from one to the other, triggering retinal degeneration in mice.

A gene mutation causes porous gut and retinal barriers, allowing bacteria to travel from one to the other, triggering retinal degeneration in mice.


Image of nerve fibers shown in green and red
Neurons Simplify Visual Signals by Responding to Only One Retina
Anne N. Connor | Oct 1, 2021 | 2 min read
Mice have neurons that connect to both eyes but only propagate the signal from one or the other, simplifying the information sent to the cerebral cortex.
Photo of newborn mouse pups
Retinal Activity Prepares Blind Newborn Mice for Vision
Ruth Williams | Jul 22, 2021 | 3 min read
Spontaneous waves of nerve impulses flowing across the retina help mouse pups practice motion detection for when they eventually open their eyes.
illustration of multiple clocks arranged in the shape of a brain
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021 | 4 min read
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
retina atrophic age-related macular degeneration amd alu line-1 l1 retrotransposon cytoplasm cdna reverse transcription replication genome dna
Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez, PhD | Feb 8, 2021 | 4 min read
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Gene Therapy in One Eye Improves Vision in Both Eyes
Abby Olena, PhD | Dec 11, 2020 | 4 min read
It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.
Pharma Looks to Outer Space to Boost Drug R&D
Katarina Zimmer | Dec 1, 2020 | 9 min read
There are benefits of studying certain biological processes under microgravity, but whether those advantages outweigh the costs of getting experiments off Earth remains to be seen.
Researchers Launch First Study of In Vivo CRISPR Therapy in Humans
Catherine Offord | Jul 26, 2019 | 1 min read
A trial is recruiting patients to test the gene-editing technology’s ability to treat an inherited form of blindness caused by a mutation in the CEP290 gene.
Donor-Derived iPS Cells Show Promise for Treating Eye Disease
Jef Akst | Apr 30, 2019 | 2 min read
Age-related macular degeneration patients who received injections of retinal cells derived from donors’ induced pluripotent stem cells have maintained their level of eyesight for a year.
gene therapy mouse mice model retinal disease retinitis pigmentosa
Image of the Day: Cone Preservation
Chia-Yi Hou | Apr 30, 2019 | 1 min read
Researchers treat mice with retinitis pigmentosa using a gene therapy that reduces cone loss.
Nanoparticles Let Mice See Near Infrared Light
Abby Olena, PhD | Feb 28, 2019 | 4 min read
Researchers injected the retinas of mice with nanoparticles that bound to photoreceptors and converted near-infrared light to green light that the animals could see.
Image of the Day: In the Eye of a Fly
Carolyn Wilke | Feb 26, 2019 | 1 min read
A missing microRNA leads to degenerating neurons and blindness in a fruit fly.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018 | 6 min read
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
Image of the Day: Retinal Transplant
Kerry Grens | Nov 7, 2018 | 1 min read
Blind rats are made to see after sheets of cells implanted into their eyes make themselves at home.
Retina Recordings Reinvented
Ruth Williams | Nov 1, 2018 | 2 min read
Ultraflexible mesh electrodes monitor the intact, functioning eyes of awake animals.
Caught on Camera
The Scientist | Nov 1, 2018 | 2 min read
Selected Images of the Day from
Image of Day: Retinas from Scratch
Ashley Yeager | Oct 12, 2018 | 1 min read
Human eye organoids could help scientists develop therapies for colorblindness.
Reprogrammed Müller Glia Restore Vision in Mice
Ashley Yeager | Aug 15, 2018 | 4 min read
A double gene-transfer therapy transformed the non-neuronal cells into rod photoreceptors in the retinas of animal models of congenital blindness.
Image of the Day: Throw the Switch
Sukanya Charuchandra | Jun 27, 2018 | 1 min read

A computer model of the eye can predict the consequences of altering the neural pathways of vision.

Image of the Day: An Eyeful
The Scientist and The Scientist Staff | Apr 30, 2018 | 1 min read
The physiological changes that can occur in the retinas of patients with cerebral malaria may provide a useful approach to diagnosis.