Donor-Derived iPS Cells Show Promise for Treating Eye Disease

Age-related macular degeneration patients who received injections of retinal cells derived from donors’ induced pluripotent stem cells have maintained their level of eyesight for a year.

| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

ABOVE: FLICKR, FARHAN PERDANA (BLEK)

The results of the first clinical trial using induced pluripotent stem cells from donors point to signs of efficacy for treating the progressive form of blindness known as age-related macular degeneration. Last week, the Japanese team of researchers reported that the first five patients to be treated are doing well and did not suffer further eyesight loss for at least a year after receiving the therapy in 2017, according to The Japan Times. One patient’s eyesight even improved.

To create the therapy, researchers reprogrammed skin cells from an anonymous donor into induced pluripotent stem cells (iPSCs), then differentiated those stem cells into a type of retinal cell that was injected into the eyes of the patients.

According to the Riken Center for Developmental Biology’s Masayo Takahashi, who led the study and described the findings at the 123rd annual meeting of the Japanese Ophthalmological Society on ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
iStock: Ifongdesign

The Advent of Automated and AI-Driven Benchwork

sampled
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo
A photo of sample storage boxes in an ultra-low temperature freezer.

Navigating Cold Storage Solutions

PHCbi logo 

Products

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo
Zymo Logo

Zymo Research Launches the Quick-16S™ Full-Length Library Prep Kit