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Retrotransposon RNA Triggers NLRC4 Inflammasome Formation: Study
Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.
Retrotransposon RNA Triggers NLRC4 Inflammasome Formation: Study
Retrotransposon RNA Triggers NLRC4 Inflammasome Formation: Study

Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.

Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic elements.

age-related macular degeneration
close-up of a retina showing blood vessels and a damaged spot
DNA in Cell Cytoplasm Implicated in Age-Related Blindness
Katarina Zimmer | Sep 29, 2021 | 5 min read
A new study suggests that DNA synthesized in the cell cytoplasm drives retinal cell death in an advanced form of age-related macular degeneration, a leading cause of blindness.
illustration of different cells types in retina
Cones Derived from Human Stem Cells Help Mice See: Study
Marcus A. Banks | Apr 23, 2021 | 3 min read
Researchers insert functioning cone photoreceptors into the retinas of mice with advanced eye disease, improving their vision.
retina atrophic age-related macular degeneration amd alu line-1 l1 retrotransposon cytoplasm cdna reverse transcription replication genome dna
Human Cells Can Synthesize DNA in Their Cytoplasm
Alejandra Manjarrez, PhD | Feb 8, 2021 | 4 min read
While studying a degenerative eye disease, researchers find the first evidence that cells produce endogenous DNA in the cytoplasm. Drugs that block this activity are linked with reduced risk of atrophic age-related macular degeneration.
Donor-Derived iPS Cells Show Promise for Treating Eye Disease
Jef Akst | Apr 30, 2019 | 2 min read
Age-related macular degeneration patients who received injections of retinal cells derived from donors’ induced pluripotent stem cells have maintained their level of eyesight for a year.
Image of the Day: Retinal Cell Implant
The Scientist Staff and The Scientist Staff | Apr 17, 2018 | 1 min read
For the first time, a transplant of replacement tissue grown from stem cells has been shown to be feasible for patients with macular degeneration.
Vision Restored: The Latest Technologies to Improve Sight
Anna Azvolinsky | Apr 10, 2018 | 5 min read
Cell implants, gene therapy, even optogenetics are making headway in clinical trials to treat various forms of blindness.  
Gene Therapy for Age-Related Macular Degeneration Safe in Humans
Diana Kwon | May 17, 2017 | 2 min read
A small Phase 1 clinical trial reports that, even at high doses, the treatment did not lead to adverse reactions.
Women Lose Vision After Stem Cell Treatment
Kerry Grens | Mar 17, 2017 | 2 min read
The adipose-derived cells were injected into the patients’ eyes to treat age-related macular degeneration. 
Bionic Eye Success
Jef Akst | Jul 23, 2015 | 2 min read
An 80-year-old man with age-related vision loss receives a retinal implant that allows him to see basic shapes.
Eye Stem Cell Therapy Moves Ahead
Kate Yandell | Apr 30, 2015 | 4 min read
Researchers inject retinal support cells derived from human embryonic stem cells into the eyes of four men with macular degeneration, bolstering evidence of the experimental treatment’s safety.
First Ever iPS-Cell Trial a Go
Bob Grant | Jul 22, 2013 | 1 min read
The Japanese government will allow a study of stem cell therapy using patients’ own cells, reprogrammed to be stem cells, to treat vision loss.
Eye Trials Give Hope for Stem Cells
Hannah Waters | Jan 24, 2012 | 4 min read
Preliminary data from human embryonic stem cell trials for two degenerative eye disorders are promising, but challenges remain for more complex tissues.
An Eye for Stem Cells
Hannah Waters | Dec 1, 2011 | 4 min read
Japanese researchers are launching an iPS cell trial for an untreatable eye disease, challenging ongoing embryonic stem cell trials.
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