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RNA Interference Comes of Age
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
RNA Interference Comes of Age
RNA Interference Comes of Age

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.

siRNA
c elegans transgenerational epigenetic inheritance behavior neuron genetics
Worm Parents Pass on Behaviors Epigenetically to Offspring
Katarina Zimmer | Jun 7, 2019 | 7 min read
Two research groups demonstrate that in Caenorhabditis elegans, behavioral traits can be passed down through the germline to future generations, even though they aren’t hard-wired.
Molecule Found in Huntington’s Patients Kills Cancer Cells
Jim Daley | Feb 12, 2018 | 2 min read
Researchers were able to slow tumor growth in a mouse model of human ovarian cancer. 
Mammalian Immunity: What’s RNAi Got to Do with It?
Shawna Williams | Jul 21, 2017 | 4 min read
A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.
Making Micromotors Biocompatible
Jyoti Madhusoodanan | Jun 1, 2016 | 8 min read
Researchers are developing potent ways to fuel and control the movement of micromotor devices.
RNA Ebola Drug Clears Animal Study
Jef Akst | Apr 24, 2015 | 1 min read
The short interfering RNA-based therapy TKM-Ebola protects monkeys from the viral strain still circulating in West Africa.
FDA OKs siRNA Ebola Drug
Kerry Grens | Sep 23, 2014 | 2 min read
The US Food and Drug Administration gives the green light to deploy an experimental short interfering RNA treatment against Ebola.
Entry Requirements
Nicholette Zeliadt | Sep 1, 2014 | 8 min read
Recent developments in cell transfection and molecular delivery technologies
Marburg Drug Shows Promise
Jyoti Madhusoodanan | Aug 21, 2014 | 2 min read
Monkeys infected with lethal doses of Marburg virus were rescued by an experimental siRNA-based therapeutic, a study shows.
RNAi Remedy Lowers Cholesterol
Abby Olena, PhD | Oct 3, 2013 | 2 min read
A Phase 1 clinical trial demonstrates the safety and efficacy of an siRNA-based, cholesterol-lowering drug.
Gene Silencing Is Golden
Carina Storrs | Aug 1, 2013 | 9 min read
A beginner’s how-to on RNAi screening in mammalian cells
Shushing RNA
Edyta Zielinska | Aug 1, 2013 | 2 min read
The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.
(Re)Programming Director
Karen Hopkin | Oct 1, 2012 | 9 min read
Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.
Dynamic Delivery
Ruth Williams | Jul 1, 2012 | 2 min read
Microscopic sponges made entirely of RNA enable efficient gene silencing.
Seeds Inherit Memories of Enemies
Amy Coombs | May 31, 2012 | 4 min read
Infested plants pass on a defense memory of pests and pathogens to help the next generation withstand invasions.
Color Explosion
Cristina Luiggi | Feb 3, 2012 | 2 min read
A fluorescence microscopy image competition straddles the boundary of science and art.
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