ADVERTISEMENT
ADVERTISEMENT
A pink graphic of an anatomical heart
The Promise of RNAi Therapeutics for Cardiovascular Disease Treatment
Kevin Fitzgerald from Alnylam Pharmaceuticals explains the potential of RNA interference for treating disease and highlights recent clinical trial successes.
The Promise of RNAi Therapeutics for Cardiovascular Disease Treatment
The Promise of RNAi Therapeutics for Cardiovascular Disease Treatment

Kevin Fitzgerald from Alnylam Pharmaceuticals explains the potential of RNA interference for treating disease and highlights recent clinical trial successes.

Kevin Fitzgerald from Alnylam Pharmaceuticals explains the potential of RNA interference for treating disease and highlights recent clinical trial successes.

siRNA

Short strands of RNA floating on a blue background
Gene Silencing with RNA Interference
Rebecca Roberts, PhD | Nov 11, 2024 | 5 min read
Gene knockdown using RNAi enables gene function studies, with applications from pest control to biotherapeutics.
oxalate cystal rnai rna interference alnylam sirna lumasiran Oxlumo Patisiran Onpattro givosiran Givlaari galnac inclisiran
RNA Interference Comes of Age
Diana Kwon | Dec 9, 2020 | 6 min read
The third FDA approval of an RNAi-based therapeutic marks the growing success of a technique that took two decades to get off the ground.
c elegans transgenerational epigenetic inheritance behavior neuron genetics
Worm Parents Pass on Behaviors Epigenetically to Offspring
Katarina Zimmer | Jun 7, 2019 | 7 min read
Two research groups demonstrate that in Caenorhabditis elegans, behavioral traits can be passed down through the germline to future generations, even though they aren’t hard-wired.
Molecule Found in Huntington’s Patients Kills Cancer Cells
Jim Daley | Feb 12, 2018 | 2 min read
Researchers were able to slow tumor growth in a mouse model of human ovarian cancer. 
Mammalian Immunity: What’s RNAi Got to Do with It?
Shawna Williams | Jul 21, 2017 | 4 min read
A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.
Making Micromotors Biocompatible
Jyoti Madhusoodanan | Jun 1, 2016 | 8 min read
Researchers are developing potent ways to fuel and control the movement of micromotor devices.
RNA Ebola Drug Clears Animal Study
Jef Akst | Apr 24, 2015 | 1 min read
The short interfering RNA-based therapy TKM-Ebola protects monkeys from the viral strain still circulating in West Africa.
FDA OKs siRNA Ebola Drug
Kerry Grens | Sep 23, 2014 | 2 min read
The US Food and Drug Administration gives the green light to deploy an experimental short interfering RNA treatment against Ebola.
Entry Requirements
Nicholette Zeliadt | Sep 1, 2014 | 8 min read
Recent developments in cell transfection and molecular delivery technologies
Marburg Drug Shows Promise
Jyoti Madhusoodanan | Aug 21, 2014 | 2 min read
Monkeys infected with lethal doses of Marburg virus were rescued by an experimental siRNA-based therapeutic, a study shows.
RNAi Remedy Lowers Cholesterol
Abby Olena, PhD | Oct 3, 2013 | 2 min read
A Phase 1 clinical trial demonstrates the safety and efficacy of an siRNA-based, cholesterol-lowering drug.
Shushing RNA
Edyta Zielinska | Aug 1, 2013 | 2 min read
The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.
Gene Silencing Is Golden
Carina Storrs | Aug 1, 2013 | 9 min read
A beginner’s how-to on RNAi screening in mammalian cells
(Re)Programming Director
Karen Hopkin | Oct 1, 2012 | 9 min read
Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.
Dynamic Delivery
Ruth Williams | Jul 1, 2012 | 2 min read
Microscopic sponges made entirely of RNA enable efficient gene silencing.
Seeds Inherit Memories of Enemies
Amy Coombs | May 31, 2012 | 4 min read
Infested plants pass on a defense memory of pests and pathogens to help the next generation withstand invasions.
Color Explosion
Cristina Luiggi | Feb 3, 2012 | 2 min read
A fluorescence microscopy image competition straddles the boundary of science and art.
ADVERTISEMENT