siRNA

Two research groups demonstrate that in Caenorhabditis elegans, behavioral traits can be passed down through the germline to future generations, even though they aren’t hard-wired.

Researchers were able to slow tumor growth in a mouse model of human ovarian cancer. 

A new study adds to the evidence that mammalian cells can use small interfering RNAs to defend against viruses, but questions remain about physiological importance.

Researchers are developing potent ways to fuel and control the movement of micromotor devices.

The short interfering RNA-based therapy TKM-Ebola protects monkeys from the viral strain still circulating in West Africa.

The US Food and Drug Administration gives the green light to deploy an experimental short interfering RNA treatment against Ebola.

Recent developments in cell transfection and molecular delivery technologies

Monkeys infected with lethal doses of Marburg virus were rescued by an experimental siRNA-based therapeutic, a study shows.

A Phase 1 clinical trial demonstrates the safety and efficacy of an siRNA-based, cholesterol-lowering drug.

The cell detains potentially harmful RNA messages in the spliceosome long enough to create interfering RNAs against the aberrant messages.

A beginner’s how-to on RNAi screening in mammalian cells

Unwilling to accept the finality of terminal differentiation, Helen Blau has honed techniques that showcase the flexibility of cells to adopt different identities.

Microscopic sponges made entirely of RNA enable efficient gene silencing.

Infested plants pass on a defense memory of pests and pathogens to help the next generation withstand invasions.

A fluorescence microscopy image competition straddles the boundary of science and art.