Whole-genome sequencing reveals a wide range of UV-induced DNA changes in human skin cells, and lighter skin collects more mutations, sometimes to “sky high” levels.

FDA researchers report that multiple active ingredients wind up in users’ bloodstream and recommend toxicology testing to investigate the clinical significance of the findings.

The Mount Sinai oncologist studies innate immune cells with the goal of designing novel immunotherapies, including cancer vaccines.

Certain populations have been historically underrepresented in genome sequencing studies, but the NIH, private clinics, and 23andMe and other companies are trying to fix that.

The increased risk is slight, but aligns with a longstanding hypothesis that having more cells in one’s body leads to more chances for those cells to become cancerous.

A molecule produced by a strain of Staphylococcus epidermis interferes with DNA synthesis.

When certain melanocyte stem cells are exposed to UV rays, a molecular cascade can trigger melanoma, scientists find in mice.

Early-stage melanoma cells alter proteins in nearby skin cells to create a favorable environment for cancer progression.

People without red hair who possess the variant are also more likely to develop this form of skin cancer, researchers report.

Rockefeller University researcher Elaine Fuchs on being a woman in science and her contributions to the burgeoning field of reverse genetics

Two compounds boost the ability of melanoma cells to invade other tissues in mice, providing additional evidence that antioxidants can be beneficial to malignant cells as well as healthy ones.

A deep-sequencing analysis reveals that non-malignant skin cells harbor many more cancer-driving mutations than previously expected. 

Researchers uncover a previously unknown way UV light can act on melanin, spurring cancer-causing mutations hours after sun exposure.

A genetic mutation tied to risk of developing testicular cancer may be more prevalent in white men because it also confers a reduced risk of developing skin cancer.

The large mammals alter the levels of melanin in their skin depending on sun exposure, helping them to avoid DNA damage.

While tracing the tricky and sometimes surprising paths of multipotent cells in the skin, mammary gland, and heart, Cédric Blanpain has repeatedly turned the stem cell field on its head.
 

Researchers identify a unique chemical signature associated with human melanoma cells that could lead to new ways to screen for the disease.
 

While exploring the genetics of a rare type of tumor, Stephen Baylin discovered an epigenetic modification that occurs in most every cancer—a finding he’s helping bring to the clinic.

Researchers identify an unexpected molecular explanation for the higher incidence of skin cancer in redheads.