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2022 Top 10 Innovations
2022 Top 10 Innovations
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
2022 Top 10 Innovations
2022 Top 10 Innovations

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.

T cell
Microscopy image of the cnidarian <em>Hydractinia symbiolongicarpus&nbsp;</em>with cell nuclei stained blue and oocytes stained yellow
Ancient Immunoglobulin Genes Help Cnidarians Decide to Fight or Fuse
Sophie Fessl, PhD | Oct 11, 2022 | 4 min read
Immunoglobulin genes might have evolved much earlier than previously expected, perhaps even in the common ancestor of Cnidarians and Bilateria, a study suggests.
3D rendered images of three T cell
T Cells Ward Off Aging with Help from Their Friends
Natalia Mesa, PhD | Sep 16, 2022 | 5 min read
Immune cells deliver packages of telomeres to T cells, helping them retain their virus-fighting function over time, research suggests.
TSS
Immune Cells and ALS: A Balance Between Life and Death
The Scientist’s Creative Services Team | 1 min read
Understanding the role of immune cells in neurodegeneration may help scientists develop new diagnostic, prognostic, and treatment tools.
Illustration showing rod-shaped Mycobacterium tuberculosis bacteria in the lungs of a person with tuberculosis
Delayed T cell Response Allows Tuberculosis to Gain Foothold in Monkeys
Anna Napolitano | Jun 1, 2022 | 5 min read
The results could help guide the design of new vaccines for the disease.
Microscopic image of nerves in the eye, a pathogen, and t cells
Science Snapshot: Eye Immunity
Lisa Winter | May 26, 2022 | 1 min read
Researchers find that tissue-resident memory T cells in the corneas of mice engender a lasting immune response.
A full blood sample vial lying on top of a piece of paper that reads &ldquo;Acute lymphoblastic leukemia&rdquo;.
Targeting Leukemia with T Cells That Avoid Self-Destruction
Deanna MacNeil, PhD | 3 min read
Researchers found that naturally-occurring CD7-negative T cells avoid self-destruction and are good effectors in CAR T therapy for T cell blood cancers.
Tiliqua rugosa, sleepy lizard, on reddish soil in western Australia
Researchers Probe Genetics Behind a Lizard’s Odd Immune System
Hannah Thomasy | May 10, 2022 | 4 min read
Deletions in the sleepy lizard genome leave it without an important type of T cells found in most other vertebrates.
illustration of thymus in white on a green background
New Mechanism for Virus-Triggered Autoimmunity Uncovered
Sophie Fessl, PhD | Mar 11, 2022 | 4 min read
Roseolovirus infection disrupts how the body trains immune cells not to attack it, a mouse study shows.
Developing Effective Cell Therapies for Challenging Cancer Types&nbsp;
Developing Effective Cell Therapies for Challenging Cancer Types
The Scientist’s Creative Services Team | 1 min read
In this webinar, Sandhya Sharma will discuss how to enrich for antigen-specific T-cells to treat virus-associated malignancies.
illustration of inside of human chest with highlighted gland between the lungs
Genetically Altered Mice Harness Benefits of Calorie Restriction  
Sophie Fessl, PhD | Feb 11, 2022 | 4 min read
A study identifies a gene that appears to be partially responsible for the health effects of a limited diet.
Salmonella (pink) invading a human epithelial cell (yellow)
Modified Salmonella Revs Immune Response, Combats Tumors in Mice
Natalia Mesa, PhD | Feb 3, 2022 | 5 min read
When coated with positively charged particles, the bacteria shuttled antigens out of tumors and activated the immune system, a study finds.
Overcoming T Cell Therapy Barriers with Engineered Proteins
Overcoming T Cell Therapy Barriers with Engineered Proteins
The Scientist’s Creative Services Team | 1 min read
Shannon Oda will discuss how to develop novel engineered fusion proteins to improve T cell therapies against hematological and solid tumors.
knitted pink heart with a mended hole
CAR T Cells Mend Broken Mouse Hearts
Sophie Fessl, PhD | Jan 6, 2022 | 4 min read
Specialized immune cells generated in vivo reduce cardiac scar tissue in mice, a new study shows.
orange and blue cell image
Woman’s Body Appears to Rid Itself of HIV
Chloe Tenn | Nov 18, 2021 | 3 min read
Researchers report what appears to be the second case of a person’s immune system clearing the virus on its own.
The Epigenetic Landscape During T Cell Exhaustion
The Epigenetic Landscape During T Cell Exhaustion
The Scientist’s Creative Services Team and 10x Genomics | 1 min read
In this webinar, E. John Wherry and Debattama Sen will discuss how epigenetic scarring of exhausted T cells influences chronic infections.
illustration of people of different genders and races
Does Biological Sex Influence COVID-19 Outcomes?
Annie Melchor | Nov 2, 2021 | 10 min read
It’s unclear whether differing odds of dying between men and women reflect inherent differences between male and female immune systems or differences rooted in gender norms.
Illustration of the BCG vaccine and resulting immune response
Infographic: TB Vaccines in the Pipeline Take Varied Approaches
Anthony King | Jul 1, 2021 | 3 min read
More than a dozen vaccines for tuberculosis are currently being tested in clinical trials. Some use whole bacteria as BCG does, while others deliver protein subunits or genetic material carried by viral vectors.  
The Many Facets of T Cell Exhaustion
The Many Facets of T Cell Exhaustion
The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read
In this webinar, Abhishek Garg will discuss using functional proteomics and multi-omics approaches to explore exhausted/dysfunctional T cell states in various cancers.
False-colored micrograph of Mycobacterium tuberculosis
Tuberculosis: The Forgotten Pandemic
Anthony King | Jul 1, 2021 | 10+ min read
This month marks the 100-year anniversary of BCG, still the only approved vaccine against the lethal pathogen. But there are new vaccines for this wily foe on the horizon.
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