What’s the Difference Between Gene Knockdown and Gene Knockout?
What’s the Difference Between Gene Knockdown and Gene Knockout?
There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.
There are many techniques that allow scientists to silence a gene, but whether the effect is transient or permanent depends on the type of approach.
TALENs
Making Standards Exceptional
Meenakshi Prabhune, PhD | Dec 4, 2023 | 9 min read
Samantha Maragh has taken on the difficult challenge of standardizing assays, data norms, and terminology in the ever evolving genome editing field.
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
New Gene Editing Tool Corrects Mutations in Mitochondrial DNA
Amanda Heidt | Jul 9, 2020 | 3 min read
An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.
Infographic: A Gene Editor for Plant Mitochondrial DNA
Ruth Williams | Mar 1, 2020 | 1 min read
New TALEN-based tools enable the organelle’s genome to be targeted and modified.
Gene Editing Reaches Plant Mitochondria
Ruth Williams | Mar 1, 2020 | 3 min read
Modified gene editing machinery enables targeted disruptions of mitochondrial genes in rice and rapeseed plants.
Genome-Edited Hornless Cows’ Offspring Are Healthy: Study
Kerry Grens | Oct 9, 2019 | 2 min read
All six calves inherited the gene for preventing horn growth, but four also got a piece of the plasmid used to introduce the sequence to their dad—complicating regulatory approval.
Gene-Edited Soybean Oil Makes Restaurant Debut
Carolyn Wilke | Mar 13, 2019 | 2 min read
A Minnesota-based company reports the sale of a soybean oil engineered to have greater stability and no trans-fat.
Gene Editing Treats Mitochondrial Disorders in Mice
Catherine Offord | Sep 25, 2018 | 2 min read
Researchers used TALENs and zinc finger nucleases to correct disease-causing mutations.
Gene Editing: From Roots to Riches
Amanda B. Keener | Oct 1, 2016 | 5 min read
Advances in genetic manipulation have simplified the once daunting task of rewriting a gene.
Thirty Years of Progress
The Scientist | Oct 1, 2016 | 1 min read
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.
Treating Cancer with CRISPR?
Jef Akst | Jun 17, 2016 | 1 min read
A federal panel will review the first proposal for the use of the technology to edit human genes for medical purposes.
Genetically Engineered Hornless Dairy Calves
Jef Akst | May 10, 2016 | 2 min read
Researchers use a gene editor to introduce an allele that eliminates the horned trait—and thus, the need for an expensive and painful process of dehorning—in dairy cows.
Gene Editing Treats Leukemia
Karen Zusi | Nov 6, 2015 | 2 min read
One-year-old Layla Richards has remained cancer-free months after receiving an experimental gene editing therapy.
Gene-Edited Pets
Karen Zusi | Oct 2, 2015 | 2 min read
Genomics giant BGI announces plans to sell “micro-pigs” it originally developed for research.
New Way to Edit Genes
Jef Akst | Oct 1, 2015 | 1 min read
Researchers develop a more-efficient method for rewriting DNA that could hold therapeutic value for HIV and other diseases.
Erasing Mitochondrial Mutations
Jenny Rood | Apr 23, 2015 | 3 min read
Researchers develop a method to selectively remove mutated mitochondrial DNA from the murine germline and single-celled mouse embryos.
Engineering TB-Resistant Cows
Jenny Rood | Mar 3, 2015 | 2 min read
Scientists add a mouse gene to the cow genome to ward off bovine tuberculosis.
A CRISPR Fore-Cas-t
Carina Storrs | Mar 1, 2014 | 8 min read
A newcomer’s guide to the hottest gene-editing tool on the block