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Accumulating lipids may be Wolbachia bacteria’s secret weapon for decreasing viral transmission.

viral replication

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Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

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Scanning Viral Genomes with 300mer Oligonucleotides

Insects Pass Antiviral Immunity to Offspring

Gene Splicing Pioneer Dale Kaiser Dies

Why Some COVID-19 Cases Are Worse than Others

Some Viruses May Infect by Inserting Different Portions of Genetic Material

Researchers Develop a Drug Against the Common Cold

Maternal Response to Zika Damages Mouse Fetuses

Ebola RNA Found Hiding in Health-Care Worker’s Lungs

CRISPR Combats Herpes

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Hidden Menace

Hide and Seek

Where Rhinovirus Replicates Best

Nipah Protein Structure Revealed

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Universe 25 Experiment

An obese mouse on the left compared with normal control on right.

How Cysteine Depletion Drives Cells to Burn Fat 

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Moss Medicines: The Next Revolution in Biotech?

Split image of a man unsuccessfully trying to tickle himself with a feather (right) and a man laughing and being tickled by a woman with a feather (left).

Why Can’t We Tickle Ourselves?

Multimedia

Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

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The Holy Grail Hunt in De Novo Antibody Design

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July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

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Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

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Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

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An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

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Products

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Sino Biological Sets New Industry Standard with ProPure Endotoxin-Free Proteins made in the USA

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Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

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Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

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Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery