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A rapid interferon response from nasal epithelial cells induces a cascade of responses during infection, from reduced viral load and cell damage to inflammation.

viral replication

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A New Piece in the HIV Replication Puzzle

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Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?

To flag neurons that have experienced genotoxic stress, researchers developed an in vivo sensor using an adeno-associated viral vector, called PRISM. Because a cell’s DNA damage response (DDR)—which activates in response to stressors such as environmental toxins or the buildup of misfolded proteins—also responds to invading pathogens, PRISM has an easier time transfecting cells whose damage response mechanisms are preoccupied with existing DNA damage. Once inside, the virus hijacks the neuron’s DNA replication machinery, which reverts an engineered frameshift mutation in the virus and thereby prompts the production of a fluorescent protein that can be observed via microscopy.

Infographic: DNA Damage Viewed with Unprecedented Clarity

Broken DNA

DNA Damage Viewed with Unprecedented Clarity

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Scanning Viral Genomes with 300mer Oligonucleotides

Insects Pass Antiviral Immunity to Offspring

Gene Splicing Pioneer Dale Kaiser Dies

Why Some COVID-19 Cases Are Worse than Others

Some Viruses May Infect by Inserting Different Portions of Genetic Material

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Kirsty Wright is searching for evidence in a missing persons investigation. She is wearing a blue shirt and glasses. Behind her is dense vegetation and police procedural tape.

How a Forensic Biologist Exposed a DNA Lab Scandal That Shook Australia

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Universe 25 Experiment

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One Gene Influences 75 Percent of Alzheimer’s Disease Cases

A picture of Rohita Roy, a postdoc at Stanford University.

Postdoc Portrait: Rohita Roy

Multimedia

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From Data to Discovery: Omics in Therapeutic Innovation

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Exploring Organoids for Disease Modeling Research

February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

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Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

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Maximizing Cancer Research Model Systems

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Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

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Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

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Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies