WIKIMEDIA, DOZENISTCells taken from adult human gums can be combined with cells from the molars of fetal mice to form teeth with viable roots, according to research published this week in the Journal of Dental Research. The method remains a long way from clinical use, but the findings represent a step toward the goal of growing bioengineered replacements for lost teeth.
Teeth develop when embryonic epithelial cells in the mouth combine with mesenchymal cells derived from the neural crest. Previous studies have shown that these cells can be combined in the lab to formal normal teeth, but the challenge was to find non-embryonic source of the cells that could be used in the clinic.
To test one such source, a team lead by King’s College London stem cell biologist Paul Sharpe extracted epithelial cells from the gums of adult humans, cultured them in the lab, and mixed them with mesenchymal tooth cells derived from embryonic mice. After a week, the researchers transplanted this mixture into the protective tissue around the kidneys of living mice, where some of the cells developed into hybrid human/mouse teeth containing dentine ...
