The Search for Persisters

Lyme disease–causing bacteria can outmaneuver antibiotics in vitro and manipulate the mouse immune system.

Written byAmanda B. Keener
| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

Borrelia burgdorferiCDC; JAMICE HANEY CARR, CLAUDIA MOLINS

It starts with a tick bite. This may be followed by the characteristic bullseye rash. And then the other symptoms of Lyme disease appear. Fever, fatigue, body aches, and headaches can all set in.

For most patients diagnosed with Lyme disease, the symptoms fade as the infection is cleared following a course of antibiotics. But for a small subset of the population, these symptoms can continue for months or years—even when diagnostic test results suggest the bacteria that causes Lyme disease, Borrelia burgdorferi, have been wiped out. Patients who present with what epidemiologist Eugene Shapiro of Yale Medical School calls “medically unexplained symptoms” are often left to seek alternative (and sometimes dangerous) treatments with limited success.

The medical community is split on post-treatment Lyme disease ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Share
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo
Abstract wireframe sphere with colorful dots and connecting lines representing the complex cellular and molecular interactions within the tumor microenvironment.

Exploring the Inflammatory Tumor Microenvironment 

Cellecta logo
An image of a DNA sequencing spectrum with a radial blur filter applied.

A Comprehensive Guide to Next-Generation Sequencing

Integra Logo

Products

brandtech logo

BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

Top Innovations 2026 Contest Image

Enter Our 2026 Top Innovations Contest

Biotium Logo

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS