Tiny Tunnels Run from the Skull to the Brain: Study

Immune cells travel through these passageways to get to injured tissue quickly, researchers say.

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ABOVE: Newly discovered channels between the skull and the brain
NAHRENDORF LAB

Never-before-seen microscopic tunnels connect the bone marrow in the skull to the lining of the brain called the meninges, researchers reported Monday (August 27) in Nature Neuroscience. The finding could offer insights to how the brain responds to injury and disease.

“We always thought that immune cells from our arms and legs traveled via blood to damaged brain tissue. These findings suggest that immune cells may instead be taking a shortcut to rapidly arrive at areas of inflammation,” Francesca Bosetti, program director at the US National Institute of Neurological Disorders and Stroke, which funded the study, says in a statement. “Inflammation plays a critical role in many brain disorders and it is possible that the newly described channels may be important in a number of conditions.”

Matthias Nahrendorf, a molecular biologist at Harvard Medical School and Massachusetts General Hospital ...

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  • Ashley Yeager

    Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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