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Revealing Immune Responses with Adaptive Immune Receptor Repertoire Profiling
Revealing Immune Responses with Adaptive Immune Receptor Repertoire Profiling
Immune receptor repertoire profiling is an important analytic tool for disease research in many areas, including cancer, cell and organ transplantation, autoimmunity, and infectious disease.
Immune receptor repertoire profiling is an important analytic tool for disease research in many areas, including cancer, cell and organ transplantation, autoimmunity, and infectious disease.
immune cells
Gut Bacteria Help T Cells Heal Muscle: Study
Natalia Mesa, PhD | Mar 14, 2023 | 4 min read
Regulatory T cells in the colon travel to muscles to promote wound healing in mice, raising questions about how antibiotics may impact injury recovery.
Targeting Antigen “Sanctuary” in Lymph Nodes Could Make Vaccines Better
Natalia Mesa, PhD | Feb 10, 2023 | 3 min read
Researchers find that small sacks inside lymph nodes contain low proteolytic activity and act as safe havens for antigens.
The Scientist's Journal Club: Transcriptomics
The Scientist’s Creative Services Team | 2 min read
Scientists discuss their latest findings on immune cell dynamics, neurodegenerative disease risk factors, and rare cell types obtained from bulk and single cell RNA sequencing experiments.
Q&A: What if Immune Cells Don’t Actually Detect Viruses and Bacteria?
Dan Robitzski | Feb 3, 2023 | 10+ min read
The Scientist spoke with Jonathan Kagan about his idea that immune cells respond to “errors” made by unsuccessful pathogens, not the pathogens themselves.
Opioids Recruit the Immune System to Cause Withdrawal Symptoms
Dan Robitzski | Jan 25, 2023 | 6 min read
A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.
PBMCs: Mononucleated and Multipurposed
Deanna MacNeil, PhD | 4 min read
Researchers employ peripheral blood mononuclear cells (PBMCs) in clinical and academic applications related to the immune system and regenerative medicine.
Opinion: Harnessing Microglia Cells to Stave Off Neurodegeneration
Kristine Zengeler, The Conversation | Dec 8, 2022 | 5 min read
Dialing up the activity of a protein called SYK in the brain’s “janitors” could provide an avenue to treat Alzheimer’s and other neurodegenerative diseases.
How Intracellular Bacteria Hijack Your Cells
Catherine Offord | Dec 1, 2022 | 10+ min read
Scientists studying pathogens such as Chlamydia, Legionella, and Listeria get a master class in how to control the internal workings of mammalian cells.
Accelerating Immune Research with Cryopreserved Peripheral Blood Mononuclear Cells
The Scientist’s Creative Services Team and MilliporeSigma | 3 min read
Commerically-available peripheral blood mononuclear cells offer a well-characterized, accessible, and consistent model for immunology and therapeutic development.
Infographic: Intracellular Bacteria’s Tricks for Host Manipulation
Catherine Offord | Dec 1, 2022 | 2 min read
Various microbes, including several human pathogens, hijack the cell’s skeleton, membranes, and protein-making machinery to make themselves at home.
Duplicated Gene Helps Bats Survive “Arms Race” With Viruses
Dan Robitzski | Nov 23, 2022 | 5 min read
Bats are known for staying healthy even while harboring viral infections. Now, research sheds light on how their unusual immune system evolved.
Connecting the Transcriptome to the Functional Proteome of Single Cells Using a Novel Platform
The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read
Rui Zheng and Patrick Paczkowski will discuss a new, highly multiplexed, simultaneous single cell transcriptomics and functional proteomics platform.
Infographic: How Immunology Can Influence Pregnancy Outcomes
Tobias R. Kollmann, Arnaud Marchant, and Sing Sing Way | Nov 14, 2022 | 3 min read
Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.
Modulating Immunity to Improve Pregnancy Outcomes
Tobias R. Kollmann, Arnaud Marchant, and Sing Sing Way | Nov 14, 2022 | 10+ min read
Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination.
How Cellular Heterogeneity Drives Immune Responses
The Scientist Creative Services Team in collaboration with 10x Genomics | 2 min read
An expert panel will discuss how single cell multiomic techniques shed new light on immune cell heterogeneity and immune function.
Chytrid Fungus Deploys Varying Strategies to Infect Amphibians
Tess Joosse | Nov 14, 2022 | 2 min read
The ability to activate different sets of genes has likely helped the chytrid fungus Batrachochytrium dendrobatidis spread widely in amphibians, resulting in global population declines.
Obesity Protects Against Genital Herpes in Mice, Study Finds
Katherine Irving | Nov 11, 2022 | 3 min read
A high-fat diet induced changes to the animals’ vaginal microbiomes that boosted survival after exposure to the virus.
Central Nervous System Modeling with iPSC-Derived Cells
The Creative Services Team in collaboration with BrainXell | 1 min read
Bryan Black and Lucas Thal will discuss their experiences screening hiPSC-derived neural cells to understand chronic pain and neuroinflammation.
Ancient Viral DNA Helps Mouse Brains Fight Infection
Natalia Mesa, PhD | Oct 24, 2022 | 3 min read
Mammals that give birth to live young may have evolved to make use of the remnants of viruses in their genomes to ward off pathogens, a study suggests.