Toddler Gets Synthetic Windpipe

Doctors culture a custom-made trachea from plastic fibers and human cells, and successfully implant it into a child who was born without the organ.

Written byDan Cossins
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

Hannah Warren and her parents JIM CARLSON/OSF SAINT FRANCIS MEDICAL CENTERHannah Warren, a 2.5-year-old girl born without a windpipe, has received a bioengineered replacement made with her own stem cells, reported The New York Times. The operation, which was carried out on April 9 at the Children’s Hospital of Illinois in Peoria, is only the sixth of its kind to be performed in the United States, and the first time the technique has been used on a child.

Warren has had a few complications but is recovering well, according to the NYT.

The scaffold and bioreactor in which the synthetic trachea was cultured with stem cells taken from bone marrow was custom-made for the patient. And although she will need a new wind pipe every few years as she grows, the researchers behind the procedure have tried to limit such replacements by including biodegradable plastic fibers to allow the trachea to stretch.

The technique has not been approved by the US Food and Drug Administration, but it was allowed to go ahead under rules permitting experimental procedures when the patient otherwise has little hope of survival.

David Warburton, director of the regenerative medicine program at the Saban Research Institute in Los Angeles, who ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies