Top 7 From F1000

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1. SWEET proteins found » A new class of proteins, dubbed SWEETs, transport glucose molecules out of plant, worm, and human cells. In some plants, SWEET proteins are co-opted by bacterial pathogens to deliver nutrition to the invaders.

L.Q. Chen et al., Nature, 468:527-32, 2010. Evaluations by G. Oldroyd, John Innes Cen; J. Schroeder, UCSD; A. Sugio & S. Hogenhout, John Innes Cen; J. Patrick, Univ Newcastle, Australia; D. Alpers, Wash U Sch of Med; B. Stieger, Univ Hosp Zurich; T. Palva, Univ Helsinki; H.E. Neuhaus, Univ Kaiserslautern. Free F1000 Evaluation

2. Good news for trauma » In a trial of more than 20,000 trauma victims, tranexamic acid, a pro-clotting agent often prescribed for excessive bleeding, was safe and reduced the risk of bleeding-related death—a finding likely to change clinical practice.

CRASH-2 trial collaborators, Lancet, 376:23-32, 2010. Evaluated by L....

3. Focus on focal adhesions » The architecture of focal adhesions—structures that mediate signaling and adhesion to the extracellular matrix—is described in vivid detail, showing several distinct strata including an integrin-signaling layer, an intermediate force-transduction layer, and an actin-regulatory layer.

P. Kanchanawong et al., Nature, 468:580-4, 2010. Evaluations by G. Danuser, Harvard Med School; M. Humphries, Univ Manchester; H. Schiller & R. Fassler, Max Planck Gesellschaft; R. Zaidel-Bar, Nat Univ Singapore; J. Couchman, Univ Copenhagen. Free F1000 Evaluation

4. Powerful tension » Tension stabilizes the attachment of microtubules to kinetochores during cell division in budding yeast, demonstrating how mechanical forces can modulate chromosome movement during replication.

B. Akiyoshi et al., Nature, 468:576-79. 2010. Evaluations by W. Earnshaw, Univ Edinburgh; R. Oliveira, Univ Oxford; Y. Dalal, NCI; E. Marco & G. Danuser, Harvard Med Sch; J. Millar, Univ Warwick; I. Cheeseman, MIT. Free F1000 Evaluation

5. Eukaryotic ribosome unveiled » The crystal structure of the translational machinery in yeast reveals unique interactions within and between the ribosome’s two subunits and promises to yield a better understanding of protein synthesis in eukaryotes.

A. Ben-Shem et al., Science, 330:1203-09, 2010. Evaluated by D. Gallie, UC Riverside; M. Elvekrog, D. MacDougall & R. Gonzalez, Columbia Univ; R. Batey, Univ Colorado Boulder; D. Ermolenko & G. Makhatadze, Rensselaer Polytechnic Inst. Free F1000 Evaluation

6. Tracking B-cell movement » Applying GFP technology in a new way, researchers tracked B-cell maturation in the lymph nodes as the cells moved from an area of rapid proliferation to an area of optimum B-cell selection and back again, identifying the essential role of T helper cells in this transition.

G.D. Victora et al., Cell, 143:592-605, 2010. Evaluated by J. Deguine & P. Bousso, Institut Pasteur; Y. Wang & D. Bhattacharya, Washington Univ; N. Harwood & F. Batista, Cancer Res UK, London Res Inst; K.-M. Toellner, Univ Birmingham. Free F1000 Evaluation

7. The genome shuffle » In some cancers chromosomes are broken apart and stitched back together, resulting in many genomic rearrangements, contravening the model of slowly accumulating point mutations. The process, dubbed “chromothripsis,” occurs in about 2–3 percent of all cancers, across many subtypes, and is active in 25 percent of bone cancers.

P.J. Stephens et al., Cell, 144:27-40, 2011. Evaluated by J. Camps & T. Ried, NCI; Y. Dalal, NCI; G. Neri, Univ Cattolica S Cuore; R. Booth, Virobay Inc; Y. Xu & M. Komiyama, Univ Tokyo. Free F1000 Evaluation

The F1000 Top 7 is a snapshot of the highest-ranked articles from a 30-day period on Faculty of 1000. Faculty Members rate the most important papers in their field. To see the latest rankings, search the database, and read daily evaluations, visit

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