Top 7 in vaccination

Neutrophil transendothelial migration, chemokinesis, and phagocytosis of bacteriaGREG LUERMAN

1. Infection from the outside

A long-standing model of bacterial infection is challenged when researchers show that virulence factors can be transferred to host cells from the surface of the pathogen rather than from its cytosol, suggesting new targets for vaccine and therapy design.

K. Akopyan et al., "Translocation of surface-localized effectors in type III secretion," PNAS,108:1639-44, 2011. Evaluated by Arto Pulliainen and Christoph Dehio, Biozentrum, Univ of Basel, Switzerland; Fabio Bagnoli and Rino Rappuoli, Novartis Vaccines and Diagnostics Srl, Italy; Raphael Valdivia, Duke Univ Med Cntr; Olivia Steele-Mortimer, Rocky Mountain Labs, NIAID; Mélanie Hamon and Pascale Cossart, Inst Pasteur, France; Peter Hume and Vassilis Koronakis, Univ of Cambridge, UK.

2. Macrophages spur cancer immunity

Macrophages that engulf dead cancer cells may play a bigger ...