Week in Review: August 17–21

Synthetic DNA–based MERS vax shows promise; fake peer review on scores of papers; gut microbes and an autoimmune eye disease; “Informed Consent” theater review

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WIKIMEDIA, SCINCESIDEA synthetic DNA–based vaccine that targets the Middle East respiratory syndrome coronavirus (MERS-CoV) triggers protective immunity in both monkeys and camels, according to a study published this week (August 19) in Science Translational Medicine.

“This type of vaccine [could allow] for a potentially more broadly neutralizing antibody response, which may protect against multiple strains of MERS-CoV circulating in the environment,” said Matthew Frieman of the University of Maryland who was not involved in the study.

“There is a clear need for development of MERS-CoV vaccines,” he added. “If there is anything to learn from the ongoing Ebola virus outbreak in West Africa, it is that proactive planning of vaccines and other therapeutics can save lives.”

NATIONAL EYE INSTITUTEGut microbes appear to trigger retina-specific T cells that can cause autoimmune uveitis in a mouse model, researchers from the US National Eye Institute (NEI) reported this week (August 18) in Immunity.

“It’s the first study to show the potential of the microbiome to induce an autoimmune disease specific to the ...

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