Why R0 Is Problematic for Predicting COVID-19 Spread

The SARS-CoV-2 pandemic has revealed the limitations of R0 as no other disease outbreak has before, at a time when policymakers need accurate forecasts.

katya katarina zimmer
| 30 min read

Register for free to listen to this article
Listen with Speechify
0:00
30:00
Share

ABOVE: © istock.com, RCLASSENLAYOUTS

On the evening of December 30, 2019, an email with the subject line “undiagnosed pneumonia – China (Hubei)” popped into Maia Majumder’s inbox. The notice, which the computational epidemiologist had received through ProMED, a global reporting system for infectious diseases, went on to describe Chinese news reports of patients pouring into hospitals in Wuhan presenting with an unexplained respiratory illness. It added: “Citizens need not panic.”

Majumder, a researcher at Harvard Medical School and Boston Children’s Hospital who had previously helped predict the spread of Saudi Arabia’s MERS epidemic of 2014 and the West African Ebola outbreak shortly thereafter, agreed with that statement—at that point, it wasn’t clear whether the culprit was an infectious pathogen capable of jumping from one person to the next. But when murmurs of possible human-to-human transmission started to circulate a few weeks later, she and her Harvard colleague Kenneth Mandl set ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • katya katarina zimmer

    Katarina Zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field. Following an internship with The Scientist in 2017, she has been happily freelancing for a number of publications, covering everything from climate change to oncology.

Published In

July/August 2020

Life During a Pandemic

Understanding the virus is just the beginning

Share
A greyscale image of cells dividing.
March 2025, Issue 1

How Do Embryos Know How Fast to Develop

In mammals, intracellular clocks begin to tick within days of fertilization.

View this Issue
Stem Cell Strategies for Skin Repair

Stem Cell Strategies for Skin Repair

iStock: Ifongdesign

The Advent of Automated and AI-Driven Benchwork

sampled
Discover the history, mechanics, and potential of PCR.

Become a PCR Pro

Integra Logo
3D rendered cross section of influenza viruses, showing surface proteins on the outside and single stranded RNA inside the virus

Genetic Insights Break Infectious Pathogen Barriers

Thermo Fisher Logo

Products

dispensette-s-group

BRAND® Dispensette® S Bottle Top Dispensers for Precise and Safe Reagent Dispensing

Sapio Sciences

Sapio Sciences Makes AI-Native Drug Discovery Seamless with NVIDIA BioNeMo

DeNovix Logo

New DeNovix Helium Nano Volume Spectrophotometer

Olink Logo

Olink® Reveal: Accessible NGS-based proteomics for every lab

Olink logo