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Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary conformation, sometimes called the native state, can be predicted from its primary amino acid sequence is also of vital importance in understanding the protein's potential capacity to form disease-inducing aggregates. MISS A FOLD, PROMPT A DISEASE Here's a list of protein folding-related disease catego

Research Briefs Eating for Two, or an Entire Lineage; Serine at the Start of Life; Interdisciplinary Research Eating for Two, or an Entire Lineage Courtesy of Randy Jirtle Duke University researchers give a new twist to the old adage, "You are what you eat." By feeding female agouti (Avy) mice methyl-rich supplements such as folic acid and vitamin B12, Randy Jirtle and Robert Waterland reduced agouti gene expression in their offspring. This change, caused by direct methylation of a transp

My alarm clock was blinking an erroneous time, but I ignored it; I had just taken a much-appreciated nap, and I needed to get back to a yeast cell biology conference at Cold Spring Harbor Laboratory. I was staying 10 miles away at a Vincentian seminary that housed students like me. My fan was running, and my cellular phone recharger was pulsing red. I had no idea that the power was coming from a backup generator. I was probably one of a few people of about 50 million, from Canada to New Jers

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