Ancient Andeans Had Novel Genetic Advantages to Adapt to Altitude

Unlike other populations living at high altitude, Andeans didn’t rely on hypoxia-related genes.

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ABOVE: Lake Titicaca is where the ancient Andean samples were found.
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Genes related to starch digestion, heart health, and immunity may have helped ancient Andean populations survive at high altitudes, researchers reported Wednesday (October 17) at the American Society of Human Genetics annual meeting in San Diego.

Previous work has shown that populations in Tibet, for instance, have specific gene variants that help them metabolize oxygen and also safeguard them against vitamin D deficiency. Studies of Ethiopians also show genetic adaptations to survive hypoxic, or low-oxygen, levels at high altitudes. “In the Andes, we don’t see anything like that,” says John Lindo, an anthropologist at Emory University in Atlanta, referring to prior investigations of Andean genetic characteristics. “People are really curious as to how they adapted to high altitude if we can’t find this genetic component.”

To search for such genetic adaptations, Lindo and his colleagues acquired the ...

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Meet the Author

  • Ashley Yeager

    Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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