Arsenic-based life debate continues

More than a dozen researchers voice their concerns about a 2010 paper that claims bacteria can use arsenic in place of phosphorus in its DNA and other biomolecules, such as proteins.

Written byJessica P. Johnson
| 3 min read

Register for free to listen to this article
Listen with Speechify
0:00
3:00
Share

Mono Lake, CaliforniaiMAGE: IMAGE © 2010 HENRY BORTMAN

Scientists are questioning the validity of a high-profile paper that claimed to have discovered a strain of bacteria from Mono Lake, California, that can use arsenic in place of phosphorus in its DNA and other biomolecules, such as proteins.

The paper, which appeared online in ScienceExpress last December, immediately sparked a hot debate among the scientific community. Now, fifteen researchers have articulated their concerns in the form of eight technical comments published in ScienceExpress last week (May 27), and, for the first time since its publication, the authors of the controversial study have written a formal response to their critics.

In general, the criticisms highlight poor experimental techniques and point to more likely explanations for the results than a straightforward replacement of phosphorous with arsenic ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies