Artificial Cells Talk to Real Ones

Nonliving cells developed in the lab can communicate chemically with living bacteria, according to a study.

Written byJef Akst
| 2 min read

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FLICKR, SURIAN SOOSAYSheref Mansy of the University of Trento in Italy and colleagues have developed artificial cells that pass a bacterial version of the Turing Test, which pits artificial intelligence (AI) against human intelligence.

Devised more than half a century ago by mathematician Alan Turing, the Turing Test states that if a computer can fool a human into thinking she is speaking with a real person, then the computer has achieved true AI. Now, Mansy’s team has developed artificial cells—encapsulated chemical systems designed to carry out particular cellular pathways, in this case, bacterial quorum sensing pathways—that have fooled real bacteria into thinking they’re alive. When cultured with Vibrio fischeri, Pseudomonas aeruginosa, or E. coli, the artificial cells began expressing certain genes in response, according to a study published last week (January 25) in ACS Central Science.

“It is absolutely possible to make artificial cells that can chemically communicate with bacteria,” Mansy told ResearchGate. “Artificial cells can sense the molecules ...

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  • Jef (an unusual nickname for Jennifer) got her master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses. After four years of diving off the Gulf Coast of Tampa and performing behavioral experiments at the Tennessee Aquarium in Chattanooga, she left research to pursue a career in science writing. As The Scientist's managing editor, Jef edited features and oversaw the production of the TS Digest and quarterly print magazine. In 2022, her feature on uterus transplantation earned first place in the trade category of the Awards for Excellence in Health Care Journalism. She is a member of the National Association of Science Writers.

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