Left to right, excerpts from: As Time Goes By; Human Hearing: A Primer; Digging for DNA© TAMI TOLPA; © CATHERINE DELPHIA; © LUCY READING-IKKANDACANCER AVATARS: Patient-derived xenograft (PDX) mice provide arguably the closest model to human cancer available without using humans themselves. PDX mice are derived from donated human tumor tissue and may be used for biomarker-driven cancer research, preclinical drug testing, or to predict the drug responses of a specific patient’s tumor.
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SEX ON THE BRAIN: Masculinization of the developing rodent brain leads to significant structural differences between the two sexes.
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AS TIME GOES BY: Aging is the outcome of diverse and complex changes in normal biological functions, from the accumulation of DNA damage to dysfunction of proteins and altered communication both within cells and among distant tissues in the body. Researchers are beginning to piece together how we age at the level of our genomes, our cells, and our whole bodies, in hopes of identifying strategies for slowing decline and extending healthy life span.
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Excerpt from Mixing It Up© LISA CLARKMIXING IT UP: Recent studies show that in the developing mouse heart, mesentery, and lumbar skin region, lymphatic vessels not only sprout from veins, but are also built from nonvenous lymphatic endothelial progenitor cells. Meanwhile, a study in zebrafish indicates that vascular progenitor cells called angioblasts, located in the main vein, give rise to different types of endothelial cell progenitors, including lymphatic progenitors, which then mature and form lymphatic vessels.
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