Skip to main content

Book Excerpt from Gene Machine

In Chapter 13, “The Final Assault,” author Venki Ramakrishnan relays the moment when he and collaborators finally solved the structure of a ribosomal subunit.

Written byVenki Ramakrishnan
| 5 min read

Register for free to listen to this article
Listen with Speechify
0:00
5:00

The end of March 2000 had finally arrived. Bil, Ditlev, Rob, and I arrived at London’s Heathrow Airport with the three dewars full of crystals. One of them was in a rectangular case, and the other two were in cases that were cylindrical with dome-shaped caps, resembling what Brian called a small thermonuclear device. Among ourselves, we referred to them as the suitcase and the bombs and had to consciously refrain from that habit at the airport when checking them in as baggage (today no airline would accept them as baggage and they now must be shipped separately by FedEx). We certainly didn’t want a zealous airline or security official opening the dewars and warming up our precious crystals.

It was an icy cold day when we landed in Chicago, rented a car at O’Hare International Airport, and drove down to Argonne where the APS was. After a fitful night’s ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member?
Add The Scientist as a preferred source on Google

Add The Scientist as a preferred Google source to see more of our trusted coverage.

Meet the Author

Related Topics

Related articles background image
The Scientist Digest cover September 2026
September 2026

Multiplex Microscopy Becomes Easier with Encoded Antibodies

A new system that enables researchers to uniquely tag monoclonal antibodies for use in microscopy could help simplify complex imaging studies.

View this Issue
Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Rethinking ALS Biomarkers: From Discovery to Clinical Impact

Alamar Biosciences logo
Best Practices for qPCR Assay Design and Optimization

Best Practices for qPCR Assay Design and Optimization

Bio-Rad
Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

Beyond the Basics: Strategies for Single-Cell and Spatial Transcriptomics Analysis

bioxcell
Scientist reviewing cellular and molecular data on a computer in a laboratory.

Building Translation-Ready Biomarkers with Connected Workflows

Danaher Logo

Products

Closeup image of a multi channel pipette dispensing pink liquid into a 96-well plate.

The ASSIST PLUS pipetting robot for affordable workflow automation

Integra Logo
Single cells in suspension

Rapidly isolate primary cells and make uniform single-cell suspensions with Corning® Cell Strainers

Corning logo
Abstract image representing cell membranes linked together.

CellBrite® Steady Membrane Stain: Cell surface staining built for real-time imaging

Biotium
sino biological logo

Monod Bio Licenses AI-designed Protein Technologies to SignalChem Biotech for Custom Discovery Assays