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Can Destroying Senescent Cells Treat Age-Related Disease?

A handful of clinical trials are underway to find out whether drugs that target senescent cells can slow the ravages of old age.

Written byKatarina Zimmer
| 33 min read

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ABOVE: © BIRGIT RITSCHKA

The little black mouse’s feet dangled above the table as the animal clutched a horizontal wire with its two front paws. After just a few seconds, it lost its grip and fell onto a pile of bedding below. For a mouse its age—just six months old, typically its physical prime—that was quite unusual. As Mayo Clinic veterinary technicians Christina Inman and Kurt Johnson knew, young mice would usually manage to hoist their hind legs up to the wire so that they’re hanging from all four limbs, allowing them to last minutes, sometimes even hours, on the endurance test.

It was late 2016, and the two vet techs were in charge of testing the physical performance of dozens of young mice as part of a study led by Mayo geriatrician and aging researcher James Kirkland. The experiment was blinded, so Inman and Johnson knew nothing of the ...

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Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

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