CRISPR-Edited Cells for Cancer Therapy Safe in Humans: Trial

In the first clinical study of its kind in the US, researchers used CRISPR to modify CAR T cells to make them more potent against cancer, but the clinical benefits are unknown.

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ABOVE: T cells attack a cancer cell, center.
FLICKR, ALEX RITTER, JENNIFER LIPPINCOTT SCHWARTZ, AND GILLIAN GRIFFITHS, NATIONAL INSTITUTE OF HEALTH

Immune cells altered by CRISPR are safe to use in cancer patients, according to results of a clinical trial reported today (February 6) in Science. While the study aimed to examine safety only, an initial look at efficacy indicates that the intervention was not a cure.

CRISPR has been touted as a revolutionary tool that has the potential to cure diseases or turn a person’s own T cells into potent cancer killers. And so researchers wanted to know: “Can CRISPR live up to its hype?” study coauthor Carl June, a cancer researcher at the University of Pennsylvania, tells HealthDay News.

June and his colleagues developed another powerful tool to ramp up T cells’ ability to attack cancer cells, the chimeric antigen receptor, or CAR, T cell treatment. In this technique, ...

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Meet the Author

  • Ashley Yeager

    Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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