A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
First Person Dosed in Novel Gene Editing Clinical Trial
First Person Dosed in Novel Gene Editing Clinical Trial

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

ABOVE: © iStock.com, vchal

CRISPR
Logo for The Scientist's 2022 Top 10 Innovations
Last Chance to Enter Our Annual Top 10 Innovations Contest
The Scientist Staff | Jul 11, 2022
There is only one week remaining to submit your new product to vie for a coveted spot in The Scientist’s 2022 competition.
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist Creative Services Team, Mirus Bio | Jul 11, 2022
A high efficiency, low toxicity method for direct RNA delivery into cells.
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl | Jun 28, 2022
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
A cockroach clings to the inside of a white mug.
Injecting Cockroaches with CRISPR Gene Edits Their Offspring
Sophie Fessl | May 25, 2022
A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD | Jun 27, 2022
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
close-up of an Aedes aegypti mosquito on human skin
Researchers Discover What Attracts Mosquitoes to Humans
Sophie Fessl | May 11, 2022
A brain area of Aedes aegypti responds specifically to components of human sebum, a study finds.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist Creative Services Team | May 19, 2022
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
Vector illustration of a courthouse with test tubes as pillars
CRISPR Patent Ruling Favors Broad Institute
Jef Akst | Mar 1, 2022
The US Patent and Trademark Office has once again decided that the institute has priority over the University of California and collaborators regarding intellectual property rights for CRISPR-Cas9 gene editing in eukaryotes. But the fight over the technique isn’t over.
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox | Dec 1, 2021
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Abstract Genetics Disease stock photo
Bridging Disciplines to Study CRISPR-Induced Chromosome Destabilization
Aparna Nathan | Apr 8, 2022
A collaboration between friends led to a cautionary finding about CRISPR’s effect on cells.
group of paleolithic people around a campfire
Gene Variant Points to Starvation’s Evolutionary Legacy
Sophie Fessl | Sep 28, 2021
Ancient and modern genomes reveal that a variant of the human growth hormone receptor likely helped our ancestors survive when food was scarce.
cartoon depiction of a pair of scissors about to cut a DNA double helix
Researchers Uncover New Families of Gene-Editing Enzymes
Annie Melchor | Sep 15, 2021
The results reveal evolutionary relatives of the Cas9 enzyme now used extensively in biotechnology.
3D virus cells attacking a DNA strand
HIV DNA Circularizes to Bypass CRISPR-Based Treatments
Nele Haelterman, PhD | Mar 7, 2022
CRISPR-mediated removal of HIV can create small, infectious DNA molecules.
photograph of miSHERLOCk device against a white background
A Self-Contained COVID-19 Test with 3-D Printed Parts
Annie Melchor | Aug 11, 2021
The makers of the CRISPR-based testing platform, called miSHERLOCK, say it could enable people at home or physicians in resource-limited environments to detect SARS-CoV-2—and eventually, other pathogens.
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
Challenges and Applications
Combinatorial Single Cell CRISPR Screens: Challenges and Applications
The Scientist Creative Services Team in collaboration with 10x Genomics | Dec 10, 2021
An expert panel will discuss how single cell sequencing enhances throughput in CRISPR gene editing applications.
Opinion: How Biomedicine Could Transform Human Reproduction
Henry T. Greely | Aug 1, 2021
CRISPR and other innovations are likely to open up a wealth of new options for how people have children.