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Researchers in George Church&rsquo;s lab modified wild type ADK proteins (left) in <em>E.coli</em>, furnishing them with an nonstandard amino acid (nsAA) meant to biocontain the resulting bacterial strain.
A Pioneer of The Multiplex Frontier
George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.
A Pioneer of The Multiplex Frontier
A Pioneer of The Multiplex Frontier

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

George Church is at it again, this time using multiplex gene editing to create virus-proof cells, improve organ transplant success, and protect elephants.

CRISPR

Scientist pipetting at the bench in white coat and purple gloves
Chek-Mate for Gliomas
Aparna Nathan, PhD | May 22, 2023 | 3 min read
New research may make immunotherapy possible for hard-to-treat brain tumors.
Editing genome stock photo
Resolving Discrepancies in Mouse and Human Autoimmunity Studies
Niki Spahich, PhD | May 15, 2023 | 4 min read
By editing primary T cells with CRISPR, researchers begin to settle a long-standing debate about a common autoimmunity risk variant.
David Liu
Targeting a Genetic Accident to Treat Disease
Deanna MacNeil, PhD | 2 min read
David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
Cell division abstract image
Versatile and Sustainable: Cell Counting for the 21st Century
The Scientist’s Creative Services Team and DeNovix Inc. | 3 min read
Discover how the latest cell counting technology is reshaping a mundane task for the future.
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins.&nbsp;
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.
A normal human liver organoid (left) stained with blue and red next to a fatty liver organoid (right) with lipid droplets stained yellow.
Working Together to Battle Fatty Liver Disorders
Niki Spahich, PhD | Mar 24, 2023 | 6 min read
Benedetta Artegiani and Delilah Hendriks are forming a joint laboratory group to understand disease mechanisms and treatments through organoid models.
COVID-19: Lessons Learned
COVID-19: Lessons Learned
The Scientist’s Creative Services Team | 2 min read
An expert panel will discuss what researchers have learned from the COVID-19 pandemic and what lessons remain for the future. 
a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
Katherine Irving | Feb 17, 2023 | 5 min read
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
The giant virus <em >Pandoravirus neocaledonia&nbsp;</em>inside the amoeba <em>Acanthamoeba castellanii</em>.
Giant Viruses Grew Out of Small Ones: Study
Kamal Nahas, PhD | Feb 13, 2023 | 4 min read
A study employing CRISPR/Cas9 to explore the evolutionary beginnings of some giant viruses finds evidence their large genomes arose from gene duplications.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist’s Creative Services Team and Mirus Bio | 3 min read
A high efficiency, low toxicity method for direct RNA delivery into cells.
A pair of prairie voles (Microtus ochrogaster)
Monogamous Rodents Don’t Need “Love Molecule” To Pair Up
Natalia Mesa, PhD | Jan 27, 2023 | 4 min read
Prairie voles lacking functional receptors for oxytocin form normal social bonds, a finding that could explain the hormone’s clinical failures.
Illustration of DNA
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist’s Creative Services Team | 1 min read
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
hundred-dollar bills disintegrating
FTX Collapse Imperils Philanthropic Research Funding
Shawna Williams | Nov 15, 2022 | 2 min read
Natural science research projects were among those promised funding by the now-collapsed crypto exchange’s “effective altruism” foundations.
Mosquito on leaf stock photo
Combating Mosquito-Borne Diseases with CRISPR
Niki Spahich, PhD | Oct 11, 2022 | 4 min read
As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.
Challenges and Applications
Combinatorial Single Cell CRISPR Screens: Challenges and Applications
The Scientist Creative Services Team in collaboration with 10x Genomics | 2 min read
An expert panel will discuss how single cell sequencing enhances throughput in CRISPR gene editing applications.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
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