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a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
Mice Pass Epigenetic Tweaks to Pups
Mice Pass Epigenetic Tweaks to Pups

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

CRISPR
The giant virus <em >Pandoravirus neocaledonia&nbsp;</em>inside the amoeba <em>Acanthamoeba castellanii</em>.
Giant Viruses Grew Out of Small Ones: Study
Kamal Nahas, PhD | Feb 13, 2023 | 4 min read
A study employing CRISPR/Cas9 to explore the evolutionary beginnings of some giant viruses finds evidence their large genomes arose from gene duplications.
A pair of prairie voles (Microtus ochrogaster)
Monogamous Rodents Don’t Need “Love Molecule” To Pair Up
Natalia Mesa, PhD | Jan 27, 2023 | 4 min read
Prairie voles lacking functional receptors for oxytocin form normal social bonds, a finding that could explain the hormone’s clinical failures.
COVID-19: Lessons Learned
COVID-19: Lessons Learned
The Scientist’s Creative Services Team | 2 min read
An expert panel will discuss what researchers have learned from the COVID-19 pandemic and what lessons remain for the future. 
Illustration of DNA
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
hundred-dollar bills disintegrating
FTX Collapse Imperils Philanthropic Research Funding
Shawna Williams | Nov 15, 2022 | 2 min read
Natural science research projects were among those promised funding by the now-collapsed crypto exchange’s “effective altruism” foundations.
Mosquito on leaf stock photo
Combating Mosquito-Borne Diseases with CRISPR
Niki Spahich, PhD | 4 min read
As alternatives to insecticides, Omar Akbari uses sophisticated genetic engineering methods to solve the world’s mosquito problems.
Illustration of a red bacteriophage infecting a blue bacterium, with other bacteria in the background.
Prokaryotes Are Capable of Learning to Recognize Phages
Patience Asanga | Aug 17, 2022 | 3 min read
Immune defense genes in bacteria and archaea can identify viral proteins, a study finds, revealing similarities between the immune systems of prokaryotic and eukaryotic organisms.
A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
Amanda Heidt | Jul 12, 2022 | 4 min read
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
Logo for The Scientist&#39;s 2022 Top 10 Innovations
Last Chance to Enter Our Annual Top 10 Innovations Contest
The Scientist Staff | Jul 11, 2022 | 1 min read
There is only one week remaining to submit your new product to vie for a coveted spot in The Scientist’s 2022 competition.
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022 | 4 min read
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
3d render illustration of Single strand ribonucleic acid.
Message in a Bottle: Developing mRNA Therapeutics
The Scientist’s Creative Services Team and Mirus Bio | 3 min read
A high efficiency, low toxicity method for direct RNA delivery into cells.
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl, PhD | Jun 28, 2022 | 7 min read
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
A cockroach clings to the inside of a white mug.
Injecting Cockroaches with CRISPR Gene Edits Their Offspring
Sophie Fessl, PhD | May 25, 2022 | 4 min read
A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.
spatial CRISPR screen for cancer
A Brave New World for Spatial Genomics in Cancer Research
Nele Haelterman, PhD | 3 min read
A new CRISPR screening technology allows scientists to recreate tumor heterogeneity in vivo and study how it affects all aspects of cancer biology.
close-up of an Aedes aegypti mosquito on human skin
Researchers Discover What Attracts Mosquitoes to Humans
Sophie Fessl, PhD | May 11, 2022 | 5 min read
A brain area of Aedes aegypti responds specifically to components of human sebum, a study finds.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa, PhD | Mar 2, 2022 | 3 min read
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist’s Creative Services Team | 1 min read
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
Vector illustration of a courthouse with test tubes as pillars
CRISPR Patent Ruling Favors Broad Institute
Jef Akst | Mar 1, 2022 | 3 min read
The US Patent and Trademark Office has once again decided that the institute has priority over the University of California and collaborators regarding intellectual property rights for CRISPR-Cas9 gene editing in eukaryotes. But the fight over the technique isn’t over.
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